Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy
Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy
复制标题
动态磁敏感对比增强灌注在颞叶癫痫中的应用
DOI：
10.1258/ar.2012.110658
复制
发表时间：
2013-02
期刊：
影响因子：
1.3
通讯作者：
Weihua Liao
中科院分区：
文献类型：
--
作者：
Wu Xing;Xiaoyi Wang;Fangfang Xie;Weihua Liao
背景 准确定位颞叶癫痫（TLE）的致痫灶在临床实践中具有重要意义。单光子发射计算机断层扫描 (SPECT) 和正电子发射断层扫描 (PET) 已广泛应用于 TLE 的偏侧化，但两者都有局限性。磁共振灌注成像可以准确、可靠地反映脑血流量和容量的差异。目的 探讨动态磁化率对比增强（DSC）灌注磁共振成像（MRI）对 TLE 致痫灶偏侧化的诊断价值。材料和方法 对 20 例 TLE 发作间期病例和 20 名健康志愿者进行常规 MRI 和 DSC-MRI 扫描。计算TLE病例和健康对照组双侧内侧颞叶的相对脑血量（rCBV）和相对脑血流量（rCBF）。比较两组来自双侧内侧颞叶 rCBV 和 rCBF 的灌注不对称指数 (AI) 的差异。结果 对照组双侧内侧颞叶rCBV（左1.55±0.32，右1.57±0.28）或rCBF（左99.00±24.61，右100.38±23.46）左右差异无统计学意义。然而，病例组同侧rCBV和rCBF值（分别为1.75±0.64和96.35±22.63）明显低于对侧（2.01±0.79和108.56±26.92；P < 0.05）。病例组rCBV AI（AIrCBV；13.03±10.33）和rCBF AI（AIrCBF；11.24±8.70）均显着高于对照组（AIrCBV 5.55±3.74，AIrCBF 5.12±3.48；P < 0.05）。以对照组 AIrCBV 和 AIrCBF 的第 95 个百分位作为正常上限，对 9 名患者的致痫灶进行了正确偏侧。结论 TLE发作间期患者同侧内侧颞叶rCBV和rCBF均显着低于健康对照者。 DSC-MRI 可以为 TLE 提供偏侧化。
Background Accurately locating the epileptogenic focus in temporal lobe epilepsy (TLE) is important in clinical practice. Single-photon emission computed tomography (SPECT) and positron-emission tomography (PET) have been widely used in the lateralization of TLE, but both have limitations. Magnetic resonance perfusion imaging can accurately and reliably reflect differences in cerebral blood flow and volume. Purpose To investigate the diagnostic value of dynamic susceptibility contrast-enhanced (DSC) perfusion magnetic resonance imaging (MRI) in the lateralization of the epileptogenic focus in TLE. Material and Methods Conventional MRI and DSC-MRI scanning was performed in 20 interictal cases of TLE and 20 healthy volunteers. The relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) of the bilateral mesial temporal lobes of the TLE cases and healthy control groups were calculated. The differences in the perfusion asymmetry indices (AIs), derived from the rCBV and rCBF of the bilateral mesial temporal lobes, were compared between the two groups. Results In the control group, there were no statistically significant differences between the left and right sides in terms of rCBV (left 1.55±0.32, right 1.57±0.28) or rCBF (left 99.00±24.61, right 100.38±23.46) of the bilateral mesial temporal lobes. However, in the case group the ipsilateral rCBV and rCBF values (1.75±0.64 and 96.35±22.63, respectively) were markedly lower than those of the contralateral side (2.01± 0.79 and 108.56±26.92; P < 0.05). Both the AI of the rCBV (AIrCBV; 13.03±10.33) and the AI of the rCBF (AIrCBF; 11.24±8.70) of the case group were significantly higher than that of the control group (AIrCBV 5.55± 3.74, AIrCBF 5.12±3.48; P < 0.05). The epileptogenic foci of nine patients were correctly lateralized using the 95th percentile of the AIrCBV and AIrCBF of the control group as the normal upper limits. Conclusion In patients with TLE interictal, both rCBV and rCBF of the ipsilateral mesial temporal lobe were markedly lower than that of healthy control subjects. DSC-MRI can provide lateralization for TLE.
登录
查看更多内容
影响因子：
--
作者：
J. Turner
通讯作者：
J. Turner
DOI：
10.1093/brain/awg108
发表时间：
2003-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
W. Paesschen;P. Dupont;G. V. Driel;H. V. Billoen;A. Maes
通讯作者：
W. Paesschen;P. Dupont;G. V. Driel;H. V. Billoen;A. Maes
影响因子：
3.5
作者：
I. Jensen
通讯作者：
I. Jensen
影响因子：
5.6
作者：
Lee, DS;Lee, JS;Lee, MC
通讯作者：
Lee, MC
影响因子：
4.4
作者：
X. Golay;M. Stuber;K. Pruessmann;D. Meier;P. Boesiger
通讯作者：
X. Golay;M. Stuber;K. Pruessmann;D. Meier;P. Boesiger