ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites.

ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites.
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DOI:
10.1093/nar/gku460
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发表时间:
2014-07
影响因子:
14.9
通讯作者:
Janežič D
Janežič D
中科院分区:
生物学2区
文献类型:
--
作者:
Konc J;Janežič D

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ProBiS-Ligands网络服务器预测配体与蛋白质结构的结合。从蛋白质结构或结合位点开始,ProBiS-Ligands首先在蛋白质数据库中识别共享相似结合位点的模板蛋白质。根据查询蛋白和发现的相似结合位点的叠加,服务器然后将这些位点的配体结构转置到查询蛋白上。这种配基预测支持许多活动,例如药物再利用。ProbiS-Ligands Web服务器是ProBiS Web服务器的扩展,对http://probis.cmm.ki.si/ligands.上的所有用户开放和免费
The ProBiS-ligands web server predicts binding of ligands to a protein structure. Starting with a protein structure or binding site, ProBiS-ligands first identifies template proteins in the Protein Data Bank that share similar binding sites. Based on the superimpositions of the query protein and the similar binding sites found, the server then transposes the ligand structures from those sites to the query protein. Such ligand prediction supports many activities, e.g. drug repurposing. The ProBiS-ligands web server, an extension of the ProBiS web server, is open and free to all users at http://probis.cmm.ki.si/ligands.
DOI: 10.1093/nar/gks435
发表时间: 2012-07
影响因子: 14.9
作者:
Konc J;Janezic D
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