Self‐Assembled Nano‐Immunostimulant for Synergistic Immune Activation
Self‐Assembled Nano‐Immunostimulant for Synergistic Immune Activation
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用于协同免疫激活的自组装纳米免疫刺激剂
DOI：
10.1002/cbic.201700246
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发表时间：
2017-09
期刊：
影响因子：
3.2
通讯作者：
Yan-Mei Li
中科院分区：
文献类型：
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作者：
Zhan-Yi Sun;Pu-Guang Chen;Yan-Fang Liu;Lei Shi;Bo-Dou Zhang;Jun-Jun Wu;Yu-Fen Zhao;Yong-Xiang Chen;Yan-Mei Li
Immunotherapy has become one of the most promising therapies for the treatment of diseases. Synthetic immunostimulants and nanomaterial immunostimulant systems are indispensable for the activation of the immune system in cancer immunotherapy. Herein, a strategy for preparing self‐assembled nano‐immunostimulants (SANIs) for synergistic immune activation is reported. Three immunostimulants self‐assemble into nanoparticles through electrostatic interactions. SANIs showed strong synergistic immunostimulation in macrophages. SANIs could also induce a strong antitumor immune response to inhibit tumor growth in mice and act as an efficient adjuvant of antitumor vaccines. Therefore, SANIs may be generally applied in cancer immunotherapy. This novel SANI strategy provides a new way for the development of both immunostimulants and ‐suppressants.
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影响因子：
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作者：
Björn Palitzsch;S. Hartmann;N. Stergiou;Markus Glaffig;E. Schmitt;H. Kunz
通讯作者：
Björn Palitzsch;S. Hartmann;N. Stergiou;Markus Glaffig;E. Schmitt;H. Kunz
DOI：
10.1073/pnas.1115166109
发表时间：
2012-01-03
影响因子：
11.1
作者：
Lakshminarayanan, Vani;Thompson, Pamela;Boons, Geert-Jan
通讯作者：
Boons, Geert-Jan
影响因子：
--
作者：
Sharareh Eskandari;R. Stephenson;A. A. Fuaad-A.;S. Apte;D. Doolan;I. Toth
通讯作者：
Sharareh Eskandari;R. Stephenson;A. A. Fuaad-A.;S. Apte;D. Doolan;I. Toth
影响因子：
--
作者：
Lutz Nuhn;S. Hartmann;Björn Palitzsch;Bastian Gerlitzki;E. Schmitt;R. Zentel;H. Kunz
通讯作者：
Lutz Nuhn;S. Hartmann;Björn Palitzsch;Bastian Gerlitzki;E. Schmitt;R. Zentel;H. Kunz
影响因子：
2.8
作者：
Cai, Hui;Huang, Zhi-Hua;Li, Yan-Mei
通讯作者：
Li, Yan-Mei