Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium.
Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium.
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DOI：
10.1136/jech-2020-214913
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发表时间：
2021-08
影响因子：
6.3
通讯作者：
McMahon AD
中科院分区：
文献类型：
--
作者：
Conway DI;Hovanec J;Ahrens W;Ross A;Holcatova I;Lagiou P;Serraino D;Canova C;Richiardi L;Healy C;Kjaerheim K;Macfarlane GJ;Thomson P;Agudo A;Znaor A;Brennan P;Luce D;Menvielle G;Stucker I;Benhamou S;Ramroth H;Boffetta P;Vilensky M;Fernandez L;Curado MP;Menezes A;Daudt A;Koifman R;Wunsch-Filho V;Yuan-Chin AL;Hashibe M;Behrens T;McMahon AD
社会经济劣势（低教育和/或收入）与头颈癌之间的关联已经得到了很好的证实，吸烟和饮酒可以解释高达四分之三的风险。我们的目的是调查与职业社会经济声望（心理社会地位的感知测量），职业社会经济地位和体力劳动经验相关的头颈癌风险的性质和解释，并评估职业暴露的潜在解释作用。汇总分析包括来自欧洲和南美的5项研究的5818例头颈癌患者（和7326例对照参与者）。终身工作经历被编码为：（1）职业社会声望-Treiman标准国际职业声望量表（SIOPS）;（2）职业社会经济地位-国际社会经济指数（ISEI）;（3）体力/非体力工作。对于从事时间最长的工作，调整吸烟、饮酒和职业性质后，观察到低SIOPS OR=1.88（95%CI：1.64至2.17）、低ISEI OR=1.74（95%CI：1.51至1.99）和手工职业OR=1.49（95%CI：1.35至1.64）的头颈部癌症风险估计值增加。经社会经济暴露相互调整后，与低SIOP相关的风险保持OR=1.59（95%CI：1.30至1.94）。这些研究结果表明，低职业社会经济声望，职位和体力劳动与头颈癌有关，吸烟，酒精和职业暴露只能部分解释这种风险。感知职业心理社会状况（SIOPS）似乎是最强的社会经济因素，相对于社会经济地位和体力/非体力工作。
The association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures. Pooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs. For the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94). These findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.
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影响因子：
4.5
作者：
Luce D;Stücker I;ICARE Study Group
通讯作者：
ICARE Study Group
DOI：
10.1093/jnci/djk179
发表时间：
2007-05-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hashibe, Mia;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo
影响因子：
4.7
作者：
McCartney, Gerry;Bartley, Mel;Wami, Welcome
通讯作者：
Wami, Welcome
影响因子：
4.8
作者：
Anantharaman, Devasena;Marron, Manuela;Macfarlane, Gary J.
通讯作者：
Macfarlane, Gary J.
影响因子：
6.3
作者：
Galobardes, B;Shaw, M;Smith, GD
通讯作者：
Smith, GD