Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France.
Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France.
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DOI：
10.1186/1471-2458-11-928
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发表时间：
2011-12-14
影响因子：
4.5
通讯作者：
ICARE Study Group
中科院分区：
文献类型：
--
作者：
Luce D;Stücker I;ICARE Study Group
呼吸道癌症的职业原因需要进一步调查：职业暴露在头颈部癌症病因学中的作用在很大程度上仍然未知，一些可疑的肺癌物质仍然存在很大的不确定性。这项研究的主要目的是调查肺癌和头颈癌的职业危险因素。ICARE是一项多中心、基于人群的病例对照研究，包括一组2926例肺癌病例、一组2415例头颈部癌病例和一组3555例受试者的共同对照组。与癌症登记处合作，在10个地理区域确定了事件病例。对照组是这些地区人口的随机抽样，按性别和年龄的分布与病例的分布相似，按社会经济地位的分布与人口的分布相似。受试者接受面对面采访，使用标准化问卷收集特别是有关烟草和酒精消费、居住史和职业史详细描述的信息。还采集了研究受试者的生物样本。主要的职业接触是石棉、人造矿物纤维、甲醛、多环芳烃、铬和镍化合物、砷、木尘、纺织尘、溶剂、强酸、切削液、二氧化硅、柴油烟雾、焊接烟雾。感兴趣的暴露的完整列表包括60多种物质。职业接触评估将使用几种补充方法：由专家对接触情况进行逐案评估;制定和使用根据调查表评估接触情况的算法;应用工作接触矩阵。大量受试者应能够发现与风险中度增加相关的暴露，并评估与不频繁或广泛分散的暴露相关的风险。将有可能研究接触不同职业风险因素的联合影响，检查职业接触、吸烟、饮酒和遗传风险因素之间的相互作用，并估计法国因职业接触而患呼吸道癌症的比例。此外，还提供了关于许多非职业风险因素的信息，这项研究将为各个领域的许多研究提供一个极好的框架。
Occupational causes of respiratory cancers need to be further investigated: the role of occupational exposures in the aetiology of head and neck cancers remains largely unknown, and there are still substantial uncertainties for a number of suspected lung carcinogens. The main objective of the study is to examine occupational risk factors for lung and head and neck cancers. ICARE is a multi-center, population-based case-control study, which included a group of 2926 lung cancer cases, a group of 2415 head and neck cancer cases, and a common control group of 3555 subjects. Incident cases were identified in collaboration with cancer registries, in 10 geographical areas. The control group was a random sample of the population of these areas, with a distribution by sex and age comparable to that of the cases, and a distribution by socioeconomic status comparable to that of the population. Subjects were interviewed face to face, using a standardized questionnaire collecting particularly information on tobacco and alcohol consumption, residential history and a detailed description of occupational history. Biological samples were also collected from study subjects. The main occupational exposures of interest are asbestos, man-made mineral fibers, formaldehyde, polycyclic aromatic hydrocarbons, chromium and nickel compounds, arsenic, wood dust, textile dust, solvents, strong acids, cutting fluids, silica, diesel fumes, welding fumes. The complete list of exposures of interest includes more than 60 substances. Occupational exposure assessment will use several complementary methods: case-by-case evaluation of exposure by experts; development and use of algorithms to assess exposure from the questionnaires; application of job-exposure matrices. The large number of subjects should allow to uncover exposures associated with moderate increase in risks, and to evaluate risks associated with infrequent or widely dispersed exposures. It will be possible to study joint effects of exposure to different occupational risk factors, to examine the interactions between occupational exposures, tobacco smoking, alcohol drinking, and genetic risk factors, and to estimate the proportion of respiratory cancers attributable to occupational exposures in France. In addition, information on many non-occupational risk factors is available, and the study will provide an excellent framework for numerous studies in various fields.
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影响因子：
6.3
作者：
MERLETTI, F;BOFFETTA, P;TERRACINI, B
通讯作者：
TERRACINI, B
影响因子：
6.4
作者：
Dietz, A;Ramroth, H;Becher, H
通讯作者：
Becher, H
影响因子：
10.4
作者：
Cogliano VJ;Grosse Y;Baan RA;Straif K;Secretan MB;El Ghissassi F;Working Group for Volume 88
通讯作者：
Working Group for Volume 88
影响因子：
4.9
作者：
Gustavsson, P;Jakobsson, R;Rutkvist, LE
通讯作者：
Rutkvist, LE
影响因子：
2.3
作者：
Boffetta, P;Gridley, G;Fraumeni, JF
通讯作者：
Fraumeni, JF