Prematurity, Birth Weight, and Socioeconomic Status Are Linked to Atypical Diurnal Hypothalamic-Pituitary-Adrenal Axis Activity in Young Adults.
Prematurity, Birth Weight, and Socioeconomic Status Are Linked to Atypical Diurnal Hypothalamic-Pituitary-Adrenal Axis Activity in Young Adults.
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早产、出生体重和社会经济地位与年轻人非典型的下丘脑-垂体-肾上腺轴昼间活动有关。
DOI：
10.1002/nur.21707
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发表时间：
2016
影响因子：
2
通讯作者：
Granger,DouglasA
中科院分区：
文献类型：
--
作者：
Winchester,SuzyBarcelos;Sullivan,MaryC;Roberts,MaryB;Granger,DouglasA
在一项前瞻性、病例对照纵向设计中，180名出生时入组的早产儿和足月儿在23岁时参加了一项综合评估组合。其中，149名年轻人，34名以前足月和115名以前早产（22名健康早产儿，48名患有医学并发症，21名患有神经系统并发症，24名小于胎龄儿）从一天内捐赠了5份唾液样本，用于测定皮质醇以评估下丘脑-垂体-肾上腺（HPA）轴的昼夜变化。进行分析，以确定是否早产类别，出生体重和社会经济地位与HPA轴功能的差异。与早产相关的产前和围产期环境影响了这个环境敏感的生理系统的活动。结果与健康和疾病的发展起源理论是一致的，并强调了早产和以后生活中的健康差异之间的联系的可能机制。© 2015威利期刊公司.
In a prospective, case‐controlled longitudinal design, 180 preterm and fullterm infants who had been enrolled at birth participated in a comprehensive assessment battery at age 23. Of these, 149 young adults, 34 formerly full‐term and 115 formerly preterm (22 healthy preterm, 48 with medical complications, 21 with neurological complications, and 24 small for gestational age) donated five saliva samples from a single day that were assayed for cortisol to assess diurnal variation of the hypothalamic–pituitary–adrenal (HPA) axis. Analyses were conducted to determine whether prematurity category, birth weight, and socioeconomic status were associated with differences in HPA axis function. Pre‐ and perinatal circumstances associated with prematurity influenced the activity of this environmentally sensitive physiological system. Results are consistent with the theory of Developmental Origins of Health and Disease and highlight a possible mechanism for the link between prematurity and health disparities later in life. © 2015 Wiley Periodicals, Inc.
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