Mitochondrial DNA disease and developmental implications for reproductive strategies.
Mitochondrial DNA disease and developmental implications for reproductive strategies.
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DOI：
10.1093/molehr/gau090
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发表时间：
2015-01
影响因子：
4
通讯作者：
Poulton J
中科院分区：
文献类型：
--
作者：
Burgstaller JP;Johnston IG;Poulton J
线粒体疾病是由线粒体功能障碍引起的潜在严重的、不可治愈的疾病。几种重要的线粒体疾病是由线粒体DNA（mtDNA）突变引起的，线粒体DNA是线粒体内包含的遗传物质，是母系遗传的。经典和现代的治疗方法存在，以解决mtDNA疾病的遗传，但可能复杂的事实，细胞mtDNA群体根据发展和生物体寿命期间的理解不深的动力学演变。我们回顾这些治疗方法和模型的mtDNA动态发展过程中，并讨论了现代mtDNA治疗这些模型的最新结果的影响。我们特别强调mtDNA分离-不同mtDNA单倍型之间增殖率的差异-作为此类治疗中潜在的和未充分探索的问题。然而，存在直接的策略来解决这个问题和其他潜在的治疗问题。特别是，我们将单倍型匹配描述为一种具有潜在改善mtDNA不相容性的任何预期问题的能力的方法。
Mitochondrial diseases are potentially severe, incurable diseases resulting from dysfunctional mitochondria. Several important mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA), the genetic material contained within mitochondria, which is maternally inherited. Classical and modern therapeutic approaches exist to address the inheritance of mtDNA disease, but are potentially complicated by the fact that cellular mtDNA populations evolve according to poorly-understood dynamics during development and organismal lifetimes. We review these therapeutic approaches and models of mtDNA dynamics during development, and discuss the implications of recent results from these models for modern mtDNA therapies. We particularly highlight mtDNA segregation—differences in proliferative rates between different mtDNA haplotypes—as a potential and underexplored issue in such therapies. However, straightforward strategies exist to combat this and other potential therapeutic problems. In particular, we describe haplotype matching as an approach with the power to potentially ameliorate any expected issues from mtDNA incompatibility.
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影响因子：
5.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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