Differentiation between external and internal cuing: an fMRI study comparing tracing with drawing.
Differentiation between external and internal cuing: an fMRI study comparing tracing with drawing.
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外部和内部提示之间的区分：fMRI研究将跟踪与图形进行比较。
DOI：
10.1016/j.neuroimage.2007.03.005
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发表时间：
2007-06
期刊：
影响因子：
5.7
通讯作者：
Miall RC
中科院分区：
文献类型：
--
作者：
Gowen E;Miall RC
外部线索运动被认为优先涉及小脑和前运动回路，而内部产生的运动招募基底神经节，前补充运动皮层（前SMA）和背外侧前额叶皮层（DLPFC）。追踪和绘图是外部和内部引导的典型动作，帕金森病患者和小脑患者分别在追踪和绘图方面表现出缺陷。在这项研究中，我们的目的是检查这种外部/内部的区别，在健康受试者使用功能成像。10名健康受试者在3-T fMRI扫描仪中使用铅笔和纸进行简单几何形状的描记和绘图。结果表明，与描记相比，绘画在右侧小脑延髓I区、双侧SMA前区、右侧背侧运动前区和右侧额叶眼区产生更大的激活。描记没有招募任何额外的激活相比，除了在纹状和纹外视觉区。因此，绘画招募的地区更频繁地与认知挑战性的任务，注意力和记忆，但基底神经节和小脑活动并没有区分跟踪绘画的假设方式。由于我们的范例是一个简单的，重复的和静态的设计，这些结果表明，任务的熟悉性和时间性质的视觉反馈跟踪任务，跟踪相比，可能是重要的影响因素对小脑参与的程度。未来的研究比较动态与静态的外部线索和视觉反馈，可能会澄清小脑和基底神经节在绘画动作的视觉指导的作用。
Externally cued movement is thought to preferentially involve cerebellar and premotor circuits whereas internally generated movement recruits basal ganglia, pre-supplementary motor cortex (pre-SMA) and dorsolateral prefrontal cortex (DLPFC). Tracing and drawing are exemplar externally and internally guided actions and Parkinson's patients and cerebellar patients show deficits in tracking and drawing, respectively. In this study we aimed to examine this external/internal distinction in healthy subjects using functional imaging. Ten healthy subjects performed tracing and drawing of simple geometric shapes using pencil and paper while in a 3-T fMRI scanner. Results indicated that compared to tracing, drawing generated greater activation in the right cerebellar crus I, bilateral pre-SMA, right dorsal premotor cortex and right frontal eye field. Tracing did not recruit any additional activation compared to drawing except in striate and extrastriate visual areas. Therefore, drawing recruited areas more frequently associated with cognitively challenging tasks, attention and memory, but basal ganglia and cerebellar activity did not differentiate tracing from drawing in the hypothesised manner. As our paradigm was of a simple, repetitive and static design, these results suggest that the task familiarity and the temporal nature of visual feedback in tracking tasks, compared to tracing, may be important contributing factors towards the degree of cerebellar involvement. Future studies comparing dynamic with static external cues and visual feedback may clarify the role of the cerebellum and basal ganglia in the visual guidance of drawing actions.
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