Mental distress, quality of life and physical symptoms in Chinese women with ovarian cancer receiving olaparib treatment during the COVID-19 pandemic.
Mental distress, quality of life and physical symptoms in Chinese women with ovarian cancer receiving olaparib treatment during the COVID-19 pandemic.
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COVID-19大流行期间接受奥拉帕尼治疗的中国卵巢癌女性患者的精神困扰、生活质量和身体症状
DOI：
10.3389/fpsyt.2022.915225
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zhao, Dan
中科院分区：
文献类型：
--
作者：
Mao, Wei;Li, Fujuan;Li, Bin;Li, Yunxia;Zhang, Xiaolan;Ou, Zhengjie;Liu, Shuai;Zhao, Dan
自新型冠状病毒病-2019年(新冠肺炎)在中国爆发以来，卵巢癌(OC)女性经历了前所未有的挑战。我们的目的是评估接受奥拉帕利治疗的OC患者的心理状态、躯体症状和生活质量(QOL)的体验，并调查新冠肺炎大流行对OC患者的影响。这项调查于2020年4月22日至5月12日在网上进行。列出了人口统计学和临床问题，以收集一般信息。采用《失眠严重程度指数》中文版、《患者健康问卷-9》、《广泛性焦虑症-7》、《事件影响量表修订版》、《癌症治疗综合功能评定》评定患者的失眠、抑郁、焦虑、应激症状和生活质量。采用多因素Logistic回归分析心理困扰和生活质量的危险因素。中国共有来自15个不同省份的56名受访者参加了调查。失眠、抑郁、焦虑、应激症状和生活质量下降的发生率分别为37.5%、51.8%、37.5%、30.4%和51.8%。疾病状况不佳、奥拉帕利服药时间较短、奥拉帕利不良事件和癌症治疗延误与心理健康问题相关。生活质量下降也与心理痛苦显著相关。这项研究强调，在家中服用奥拉帕利的女性，精神健康问题和生活质量下降应该得到更多的关注。在新冠肺炎大流行期间，对OC患者采取适当的心理保健策略是必要的。
Women with ovarian cancer (OC) have experienced unprecedented challenges since the novel coronavirus disease-2019 (COVID-19) outbreak in China. We aim to evaluate the experience of psychological status, physical symptoms and quality of life (QoL) and investigate the impact of COVID-19 pandemic on OC patients receiving olaparib. The survey was conducted online from April 22 to May 12 in 2020. Demographic and clinical questions were listed to collect general information. The degree of insomnia, depression, anxiety, stress symptoms and QoL were assessed by the Chinese versions of the Insomnia Severity Index, the Patient Health Questionnaire-9, the Generalized Anxiety Disorder-7, the Impact of Event Scale-Revised, and the General Functional Assessment of Cancer Therapy, respectively. Multivariate logistic regression analysis was conducted to analyze the risk factors for mental distress and QoL. A total of 56 respondents coming from 15 various provinces in China participated in the survey. The prevalence of insomnia, depressive, anxiety, stress symptoms and reduced QoL were 37.5, 51.8, 37.5, 30.4, and 51.8%, respectively. Unfavorable disease status, shorter period of olaparib administration, adverse events of olaparib and delay in cancer care were correlated with mental health problems. Reduced QoL was also significantly associated with psychological distress. This study emphasized that mental health problems and reduced QoL should gain more attention in women with OC who are receiving oral olaparib at home. Appropriate psychological healthcare strategies are necessary for OC patients during the COVID-19 pandemic.
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影响因子：
4
作者：
Gultekin M;Ak S;Ayhan A;Strojna A;Pletnev A;Fagotti A;Perrone AM;Erzeneoglu BE;Temiz BE;Lemley B;Soyak B;Hughes C;Cibula D;Haidopoulos D;Brennan D;Cola E;van der Steen-Banasik E;Urkmez E;Akilli H;Zapardiel I;Tóth I;Sehouli J;Zalewski K;Bahremand K;Chiva L;Mirza MR;Papageorgiou M;Zoltan N;Adámková P;Morice P;Garrido-Mallach S;Akgor U;Theodoulidis V;Arik Z;Steffensen KD;Fotopoulou C
通讯作者：
Fotopoulou C
影响因子：
4
作者：
Javellana, Melissa;Hlubocky, Fay J.;Lee, Nita K.
通讯作者：
Lee, Nita K.
影响因子：
4.7
作者：
Bodurka-Bevers, D;Basen-Engquist, K;Gershenson, DM
通讯作者：
Gershenson, DM
影响因子：
7
作者：
Wang, Wenzheng;Bian, Qian;Zhao, Min
通讯作者：
Zhao, Min
DOI：
10.1016/s1470-2045(18)30343-7
发表时间：
2018-08
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Friedlander M;Gebski V;Gibbs E;Davies L;Bloomfield R;Hilpert F;Wenzel LB;Eek D;Rodrigues M;Clamp A;Penson RT;Provencher D;Korach J;Huzarski T;Vidal L;Salutari V;Scott C;Nicoletto MO;Tamura K;Espinoza D;Joly F;Pujade-Lauraine E
通讯作者：
Pujade-Lauraine E