Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
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DOI：
10.1186/1471-2202-13-67
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发表时间：
2012-06-15
期刊：
影响因子：
2.4
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhao S;Yu Z;Zhao G;Xing C;Hayakawa K;Whalen MJ;Lok JM;Lo EH;Wang X
Accumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries. In this study we tested the neuroprotective effects of Ngb over-expression against traumatic brain injury (TBI) in mice. Both Ngb over-expression transgenic (Ngb-Tg) and wild-type (WT) control mice were subjected to TBI induced by a controlled cortical impact (CCI) device. TBI significantly increased Ngb expression in the brains of both WT and Ngb-Tg mice, but Ngb-Tg mice had significantly higher Ngb protein levels at the pre-injury baseline and post-TBI. Production of oxidative tissue damage biomarker 3NT in the brain was significantly reduced in Ngb-Tg mice compared to WT controls at 6 hours after TBI. The traumatic brain lesion volume was significantly reduced in Ngb Tg mice compared to WT mice at 3 weeks after TBI; however, there were no significant differences in the recovery of sensorimotor and spatial memory functional deficits between Ngb-Tg and WT control mice for up to 3 weeks after TBI. Ngb over-expression reduced traumatic lesion volume, which might partially be achieved by decreasing oxidative stress.
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DOI：
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发表时间：
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DOI：
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DOI：
10.1073/pnas.0637726100
发表时间：
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影响因子：
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作者：
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