Adverse Childhood Experiences and Association With Pediatric Asthma Severity in the 2016-2017 National Survey of Children's Health.
Adverse Childhood Experiences and Association With Pediatric Asthma Severity in the 2016-2017 National Survey of Children's Health.
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DOI：
10.1016/j.acap.2021.04.021
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发表时间：
2021-08
影响因子：
3.1
通讯作者：
Szilagyi PG
中科院分区：
文献类型：
--
作者：
Ross MK;Romero T;Szilagyi PG
先前的研究发现，不良童年经历（ACE）与哮喘的患病率和发作有关，可能与压力和炎症增加有关。我们假设ACE也可能与哮喘严重程度相关。我们研究了2016-2017年美国全国儿童健康调查数据集，以探索ACE与儿童哮喘严重程度之间的关系。我们分析了0至17岁的儿童，他们目前患有由医疗保健提供者诊断的哮喘。我们使用卡方方差分析（ANOVA）报告描述性特征，并使用多变量回归分析评估累积和个体ACE与哮喘严重程度的关系。采用了调查抽样权重和SAS调查程序，以产生具有全国代表性的结果。我们的分析包括3691名儿童，代表人口5，465，926。未经调整的分析表明，ACE-特别是家庭经济困难，父母/监护人在监狱服刑，目睹家庭暴力，或邻里暴力的受害者/证人-与中度/重度哮喘的几率较高。在控制了可能与暴露（ACE）和结果（哮喘严重程度）相关的混杂因素后，目睹父母/成人暴力的儿童有更高的调整后的中度/重度哮喘的几率。(1.67家庭内目击的家庭暴力与儿童报告的中度/重度哮喘显著相关。
Prior studies have found that adverse childhood experiences (ACEs) are associated with asthma prevalence and onset, presumably related to stress and increased inflammation. We hypothesized that ACEs may be associated with asthma severity as well. We studied the 2016–2017 US National Survey of Children’s Health dataset to explore the relationship between ACEs and pediatric asthma severity. We analyzed children ages 0 to 17 years old who had current caregiver-reported asthma diagnosed by a healthcare provider. We reported descriptive characteristics using chi-square analysis of variance (ANOVA) and used multivariable regression analysis to assess the relationship of cumulative and individual ACEs with asthma severity. Survey sampling weights and SAS survey procedures were implemented to produce nationally representative results. Our analysis included 3691 children, representing a population of 5,465,926. Unadjusted analysis demonstrated that ACEs – particularly household economic hardship, parent/guardian served time in jail, witnessed household violence, or victim/witness of neighborhood violence – were each associated with higher odds of moderate/severe caregiver-reported asthma. After controlling for confounders possibly associated with both exposure (ACEs) and outcome (asthma severity), children who witnessed parent/adult violence had higher adjusted odds of caregiver-reported moderate/severe asthma. (1.67, confidence interval 1.05–2.64, P = .03) Intrafamilial witnessed household violence is significantly associated with caregiver-reported moderate/severe asthma.
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影响因子：
14.2
作者：
Rosenberg, Stacy L.;Miller, Gregory E.;Celedon, Juan C.
通讯作者：
Celedon, Juan C.
影响因子：
24.3
作者：
Chung, Kian Fan;Wenzel, Sally E.;Teague, W. Gerald
通讯作者：
Teague, W. Gerald
影响因子：
4.1
作者：
Bhan N;Glymour MM;Kawachi I;Subramanian SV
通讯作者：
Subramanian SV
DOI：
10.1164/rccm.201210-1789oc
发表时间：
2013-03-15
影响因子：
24.7
作者：
Chen, Wei;Boutaoui, Nadia;Celedon, Juan C.
通讯作者：
Celedon, Juan C.
影响因子：
2.3
作者：
Brick, J M;Kalton, G
通讯作者：
Kalton, G