Irradiation-induced polyploid giant cancer cells are involved in tumor cell repopulation via neosis.
Irradiation-induced polyploid giant cancer cells are involved in tumor cell repopulation via neosis.
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辐射诱导的多倍体巨型癌细胞通过新形成参与肿瘤细胞再增殖
DOI：
10.1002/1878-0261.12913
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发表时间：
2021-08
影响因子：
6.6
通讯作者：
Huang Q
中科院分区：
文献类型：
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作者：
Zhang Z;Feng X;Deng Z;Cheng J;Wang Y;Zhao M;Zhao Y;He S;Huang Q
当在治疗中存活下来的残余肿瘤细胞顽强增殖并重新形成肿瘤时，肿瘤再增殖就会发生。这一过程背后的细胞和分子机制仍知之甚少。在这项研究中，我们提出多倍体巨癌细胞（PGCCs）在放疗后通过新有丝分裂参与肿瘤再增殖。我们发现，尽管放疗诱导的大多数PGCCs发生了细胞死亡，但一些PGCCs表现出增殖能力。利用延时显微镜和单细胞克隆实验，我们观察到增殖的PGCCs进行新有丝分裂，从而促进放疗后的肿瘤细胞再增殖。值得注意的是，从濒死肿瘤细胞中释放的高迁移率族蛋白B1（HMGB1）而非细胞内的HMGB1能够促进基于新有丝分裂的肿瘤再增殖，并且使用HMGB1抑制剂可以抑制后者。总之，我们的研究结果表明，PGCC能够在放疗后通过新有丝分裂引发肿瘤再增殖。
在这项研究中，我们提出多倍体巨癌细胞（PGCCs）在放疗后参与肿瘤再增殖。尽管放疗诱导的大多数PGCCs发生了细胞死亡，但一些PGCCs表现出增殖能力，被确定为新有丝分裂。从濒死肿瘤细胞中释放的HMGB1而非细胞内的HMGB1能够促进基于新有丝分裂的肿瘤再增殖。
Tumor repopulation occurs when residual tumor cells surviving therapies tenaciously proliferate and re‐establish the tumor. The cellular and molecular mechanisms underlying this process remain poorly understood. In this study, we propose that polyploid giant cancer cells (PGCCs) are involved in tumor repopulation via neosis following radiotherapy. We found that although the majority of PGCCs induced by irradiation underwent cell death, some PGCCs exhibited proliferative capacity. Utilizing time‐lapse microscopy and single‐cell cloning assays, we observed that proliferating PGCCs underwent neosis, thereby contributing to tumor cell repopulation after irradiation. Notably, HMGB1 released from dying tumor cells rather than intracellular HMGB1 could promote neosis‐based tumor repopulation, and the latter could be suppressed by the use of HMGB1 inhibitors. Taken together, our results indicate that PGCC can initiate tumor repopulation via neosis following radiation therapy. In this study, we propose that polyploid giant cancer cells (PGCCs) are involved in tumor repopulation following radiotherapy. Although the majority of PGCCs induced by irradiation underwent cell death, some PGCCs exhibited proliferative capacity, identified as neosis. HMGB1 released from dying tumor cells rather than intracellular HMGB1 could promote neosis‐based tumor repopulation.
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DOI：
10.1038/nrm2718
发表时间：
2009-07
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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多倍体巨癌细胞的形成涉及局部晚期直肠癌新辅助放化疗的预后价值
影响因子：
--
作者：
Fei, Fei;Zhang, Mingqing;Zhang, Shiwu
通讯作者：
Zhang, Shiwu
受辐射的肿瘤细胞释放的 HMGB1 通过旁分泌作用促进活肿瘤细胞增殖
影响因子：
9
作者：
He S;Cheng J;Sun L;Wang Y;Wang C;Liu X;Zhang Z;Zhao M;Luo Y;Tian L;Li C;Huang Q
通讯作者：
Huang Q
影响因子：
14.5
作者：
Liu J
通讯作者：
Liu J
Caspase 3 介导的癌症放射治疗过程中肿瘤细胞增殖的刺激。
影响因子：
82.9
作者：
通讯作者：
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