Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis.
Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis.
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慢性炎症相关的DNA损伤反应：贲门癌发生的驱动力
DOI：
10.18632/oncotarget.3091
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发表时间：
2015-02-20
期刊：
影响因子：
--
通讯作者：
Su M
中科院分区：
文献类型：
--
作者：
Lin R;Xiao D;Guo Y;Tian D;Yun H;Chen D;Su M
贲门癌（GCC）是一种与慢性炎症相关的高度侵袭性疾病。为了探讨DNA损伤反应（DDR）与慢性炎症的关系，我们在食管癌和贲门癌高发地区潮汕沿岸采集了100例非肿瘤贲门标本。重度慢性炎症发生在发育不良的上皮组织中（80.9%），明显高于非发育不良组织（40.7%）（P<0.001）。免疫组化分析显示，DNA损伤反应与慢性炎症从正常到严重程度平行（P<0.05）。我们发现DNA损伤反应随着癌前病变的进展而逐渐增加（P<0.05）。这些发现为持续慢性炎症相关的DNA损伤反应可能是贲门癌变的驱动力提供了病理证据。基于这些发现，非恶性组织中的DNA损伤反应可能成为预测贲门恶性转化的有前景的生物医学标志物。
Gastric cardia cancer (GCC) is a highly aggressive disease associated with chronic inflammation. To investigate the relationship between DNA damage response (DDR) and chronic inflammation, we collected 100 non-tumor gastric cardia specimens of Chaoshan littoral, a high-risk region for esophageal and gastric cardia cancer. A significantly higher proportion of severe chronic inflammation was found in dysplastic epithelia (80.9%) in comparison with that in non-dysplastic tissues (40.7%) (P<0.001). Immunohistochemical analysis demonstrated that DNA damage response was parallel with the chronic inflammation degrees from normal to severe inflammation (P<0.05). We found that DNA damage response was progressively increased with the progression of precancerous lesions (P<0.05). These findings provide pathological evidence that persistent chronic inflammation-related DNA damage response may be a driving force of gastric cardia carcinogenesis. Based on these findings, DNA damage response in non-malignant tissues may become a promising biomedical marker for predicting malignant transformation in the gastric cardia.
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