Brain iron concentrations in regions of interest and relation with serum iron levels in Parkinson disease.
Brain iron concentrations in regions of interest and relation with serum iron levels in Parkinson disease.
复制标题
DOI：
10.1016/j.jns.2017.04.035
复制
发表时间：
2017-07-15
影响因子：
4.4
通讯作者：
Anzai Y
中科院分区：
文献类型：
--
作者：
Costa-Mallen P;Gatenby C;Friend S;Maravilla KR;Hu SC;Cain KC;Agarwal P;Anzai Y
Brain iron has been previously found elevated in the substantia nigra pars compacta (SNpc), but not in other brain regions, of Parkinson’s disease (PD) patients. However, iron in circulation has been recently observed to be lower than normal in PD patients. The regional selectivity of iron deposition in brain as well as the relationship between SNpc brain iron and serum iron within PD patients has not been completely elucidated. In this pilot study we measured brain iron in six regions of interest (ROIs) as well as serum iron and serum ferritin, in 24 PD patients and 27 age- gender- matched controls. Brain iron was measured on magnetic resonance imaging (MRI) with a T2 prime (T2’) method. Difference in brain iron deposition between PD cases and controls for the six ROIs were calculated. SNpc / white matter brain iron ratios and SNpc/ serum iron ratios were calculated for each study participant, and differences between PD patients and controls were tested. PD patients overall had higher brain iron than controls in the SNpc. PD patients had significantly higher SNpc / white matter brain iron ratios than controls, and significantly higher brain SNpc iron / serum iron ratios than controls. These results indicate that PD patients’ iron metabolism is disrupted toward a higher partitioning of iron to the brain SNpc at the expenses of iron in the circulation.
登录
查看更多内容
影响因子：
14.5
作者：
Griffiths, PD;Dobson, BR;Clarke, DT
通讯作者：
Clarke, DT
影响因子：
4.1
作者：
Koziorowski, Dariusz;Friedman, Andrzej;Dziewulska, Dorota
通讯作者：
Dziewulska, Dorota
DOI：
10.1016/j.jtemb.2005.08.003
发表时间：
2005-01-01
影响因子：
3.5
作者：
Forte, G;Alimonti, A;Bocca, B
通讯作者：
Bocca, B
影响因子：
9.9
作者：
GIBB, WRG;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
4.8
作者：
Hochstrasser, H;Tomiuk, J;Berg, D
通讯作者：
Berg, D