Brain perfusion by arterial spin labeling MRI in multiple sclerosis.
Brain perfusion by arterial spin labeling MRI in multiple sclerosis.
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多发性硬化症中动脉自旋标记 MRI 的脑灌注。
DOI：
10.1007/s00415-015-7792-6
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发表时间：
2015
影响因子：
6
通讯作者：
Inglese,Matilde
中科院分区：
文献类型：
--
作者：
Koudriavtseva,Tatiana;Plantone,Domenico;Renna,Rosaria;Inglese,Matilde
MRI在多发性硬化症（MS）中的作用已经确立了几十年。此外，已经开发了新的MRI技术，以更好地了解这种疾病的复杂发病机制，因为常规MRI技术的使用部分受限于其与临床特征的弱相关性以及对灰质（GM）受累和白色物质（WM）弥漫性损伤的低敏感性[1]。这些局限性在疾病从主要炎性阶段转变为退行性阶段时变得更加显著[1] JS传统上被认为是中枢神经系统的脱髓鞘炎性疾病;然而，血管受累和灌注异常最近受到越来越多的关注[2]。早期的PET和SPECT研究显示认知受损MS患者存在代谢改变和灌注缺陷，特别是在左额叶和颞叶的皮质水平[3]。最近，动态磁敏感对比增强（DSC）MRI显示MS的整体减少，但区域混合脑血流量（CBF）。在复发缓解型MS（RRMS）患者中，在外观正常的WM（NAWM）[4-7]和深部GM [6，7]中均证实了CBF降低，与临床孤立综合征（CIS）患者相比，其壳核中的CBF也显著降低[7]。
The role of MRI in multiple sclerosis (MS) has been well established for decades. Moreover, new MRI techniques have been developed to better understand the complex pathogenesis of this disease, since the use of conventional MRI techniques is partially limited by its weak associations with clinical features and low sensitivity for gray matter (GM) involvement and diffuse damage of white matter (WM)[1]. These limitations become even more significant in the disease shift from the predominantly inflammatory to degenerative phase [1].MS has been traditionally considered a demyelinating inflammatory disorder of the central nervous system; however, vascular involvement and perfusion abnormalities are recently receiving an increasing interest [2]. Earlier PET and SPECT studies showed metabolic alterations and perfusion deficits in cognitively impaired MS patients, particularly at the cortical level in the left frontal and temporal lobes [3]. Recently, a dynamic susceptibility contrast-enhanced (DSC) MRI showed in MS a globally reduced but regionally mixed cerebral blood flow (CBF). Decreased CBF has been demonstrated in both normalappearing WM (NAWM)[4–7] and deep GM [6, 7] in relapsing–remitting MS (RRMS) patients, which had also a significantly reduced CBF in the putamen compared to patients with clinically isolated syndrome (CIS)[7].
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