Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease.
Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease.
复制标题
DOI：
10.1371/journal.pone.0053587
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Groupe d’Investigation du Liquide Cephalorachidien (GIL) Study Network
中科院分区：
文献类型：
--
作者：
Dumurgier J;Mouton-Liger F;Lapalus P;Prevot M;Laplanche JL;Hugon J;Paquet C;Groupe d’Investigation du Liquide Cephalorachidien (GIL) Study Network
阿尔茨海默病(AD)患者脑脊液(CSF)中促凋亡蛋白受体(PKR)及其磷酸化PKR(PPKR)水平升高，但脑脊液PKR水平是否与AD患者认知功能减退有关尚不清楚。本研究包括来自我们记忆诊所的41例AD患者和11例遗忘性轻度认知障碍(AMCI)患者。临床诊断后1个月行腰椎穿刺术，平均随访2年，每6个月复查一次简易智力状态检查(MMSE)。在AD患者中，使用调整了年龄和性别的线性混合模型来评估MMSE评分与基线脑脊液中Aβ肽(Aβ1-42)、Tau、磷酸化Tau(p-Tau181)、PKR和pPKR水平之间的横断面和纵向关联。基线时的平均(SD)MMSE为20.5(6.1)，MMSE评分在随访期间下降(-0.12分/月，标准差[SE] = 0.03)。基线时MMSE越低，脑脊液Aβ1-42和p-Tau181/Tau比值越低。PPKR水平与随访期间MMSE的纵向变化相关，较高的PPKR水平与认知恶化加剧相关。其他脑脊液生物标志物与MMSE随时间的变化无关。在aMCI患者中，转化为AD的患者与未转化的患者的平均脑脊液生物标志物水平没有差异。这些结果表明，在AD诊断时，较高的脑脊液pPKR水平可以预测认知功能减退的更快速度。
The cerebrospinal fluid (CSF) levels of the proapoptotic kinase R (PKR) and its phosphorylated PKR (pPKR) are increased in Alzheimer’s disease (AD), but whether CSF PKR concentrations are associated with cognitive decline in AD patients remain unknown. In this study, 41 consecutive patients with AD and 11 patients with amnestic mild cognitive impairment (aMCI) from our Memory Clinic were included. A lumbar puncture was performed during the following month of the clinical diagnosis and Mini-Mental State Examination (MMSE) evaluations were repeated every 6 months during a mean follow-up of 2 years. In AD patients, linear mixed models adjusted for age and sex were used to assess the cross-sectional and longitudinal associations between MMSE scores and baseline CSF levels of Aβ peptide (Aβ 1-42), Tau, phosphorylated Tau (p-Tau 181), PKR and pPKR. The mean (SD) MMSE at baseline was 20.5 (6.1) and MMSE scores declined over the follow-up (-0.12 point/month, standard error [SE] = 0.03). A lower MMSE at baseline was associated with lower levels of CSF Aβ 1–42 and p-Tau 181/Tau ratio. pPKR level was associated with longitudinal MMSE changes over the follow-up, higher pPKR levels being related with an exacerbated cognitive deterioration. Other CSF biomarkers were not associated with MMSE changes over time. In aMCI patients, mean CSF biomarker levels were not different in patients who converted to AD from those who did not convert.These results suggest that at the time of AD diagnosis, a higher level of CSF pPKR can predict a faster rate of cognitive decline.
登录
查看更多内容
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
9.9
作者：
Henneman, W. J. P.;Vrenken, H.;van der Flier, W. M.
通讯作者：
van der Flier, W. M.
影响因子：
9.9
作者：
Seppala, T. T.;Nerg, O.;Herukka, S. -K.
通讯作者：
Herukka, S. -K.
DOI：
10.1523/jneurosci.3785-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
4.7
作者：
Chang, RCC;Suen, KC;Hugon, J
通讯作者：
Hugon, J