Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation.
Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation.
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DOI：
10.1038/s41598-023-48851-6
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发表时间：
2023-12-06
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
骨质量通常用于诊断骨质疏松症等骨疾病，许多研究集中在骨折预测的微结构上。在本研究中，使用显微计算机断层扫描（µCT）和断层合成（使用焦点结构几何结构（FCG））对牛股骨远端进行成像，以比较微结构参数。两种成像模式之间的六个感兴趣区域（ROI）进行了比较，使用全局和自适应方法对图像进行二值化。将FCG图像下采样至与µCT图像相同的像素大小。使用BoneJ确定每种成像模式、二值化技术和ROI的骨形态计量学。发现FCG和µCT之间的骨面积/总面积几乎没有显著差异（对于6个ROI中的2个，p < 0.05）。分形维数在µCT和下采样FCG（像素大小相等）之间只有一个显著差异（对于六个ROI之一，p < 0.05）。观察到骨小梁厚度和骨小梁间距遵循相应µCT图像观察到的趋势，尽管许多绝对值存在显著差异（根据使用的图像类型，1至6个ROI之间的p < 0.05）。这项研究表明，实用的断层合成测量的微结构形态。
Bone quality is commonly used to diagnose bone diseases such as osteoporosis, with many studies focusing on microarchitecture for fracture prediction. In this study a bovine distal femur was imaged using both micro-computed tomography (µCT) and tomosynthesis using focal construct geometry (FCG) for comparison of microarchitectural parameters. Six regions of interest (ROIs) were compared between the two imaging modalities, with both global and adaptive methods used to binarize the images. FCG images were downsampled to the same pixel size as the µCT images. Bone morphometrics were determined using BoneJ, for each imaging modality, binarization technique and ROI. Bone area/total area was found to have few significant differences between FCG and µCT (p < 0.05 for two of six ROIs). Fractal Dimension had only one significant difference (p < 0.05 for one of six ROIs) between µCT and downsampled FCG (where pixel size was equalized). Trabecular thickness and trabecular spacing were observed to follow trends as observed for the corresponding µCT images, although many absolute values were significantly different (p < 0.05 for between one and six ROIs depending on image types used). This study demonstrates the utility of tomosynthesis for measurement of microarchitectural morphometrics.
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影响因子：
3.8
作者：
CHUNG, HW;CHU, CC;WEHRLI, FW
通讯作者：
WEHRLI, FW
影响因子：
3.5
作者：
Dicken, A. J.;Evans, J. P. O.;Zioupos, P.
通讯作者：
Zioupos, P.
影响因子：
3.8
作者：
Evans, J. P. O.;Godber, S. X.;Rogers, K. D.
通讯作者：
Rogers, K. D.
DOI：
10.1002/jbmr.4449
发表时间：
2021-12
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
通讯作者：
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影响因子：
3.8
作者：
Elarnaut, F.;Evans, J. P. O.;Rogers, K. D.
通讯作者：
Rogers, K. D.