Prediction of peptides retention behavior in reversed-phase liquid chromatography based on their hydrophobicity.
Prediction of peptides retention behavior in reversed-phase liquid chromatography based on their hydrophobicity.
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DOI：
10.1002/jssc.202200743
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发表时间：
2023-01
影响因子：
3.1
通讯作者：
Williams, Daryl R.
中科院分区：
文献类型：
--
作者：
Al Musaimi, Othman;Valenzo, Oscar M. Mercado;Williams, Daryl R.
疏水性是多肽和蛋白质的重要物理化学性质。它负责它们的构象变化、稳定性以及各种化学分子内和分子间相互作用。人们已经投入了大量的精力来研究疏水性的程度以及它如何影响各种生物过程，以及它在分离和纯化奋进中的关键作用。在这里，我们回顾了为确定疏水性而进行的各种研究，从（i）简单的氨基酸溶解度行为开始，（ii）在反相液相色谱模式下进行的实验方法，并以（iii）更先进的计算和机器学习模型的一些例子结束。
Hydrophobicity is an important physicochemical property of peptides and proteins. It is responsible for their conformational changes, stability, as well as various chemical intramolecular and intermolecular interactions. Enormous efforts have been invested to study the extent of hydrophobicity and how it could influence various biological processes, in addition to its crucial role in the separation and purification endeavor as well. Here, we have reviewed various studies that were carried out to determine the hydrophobicity starting from (i) simple amino acids solubility behavior, (ii) experimental approach that was undertaken in the reversed‐phase liquid chromatography mode, and ending with (iii) some examples of more advanced computational and machine learning models.
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影响因子：
2.9
作者：
BROWNE, CA;BENNETT, HPJ;SOLOMON, S
通讯作者：
SOLOMON, S
DOI：
10.3390/ph15020222
发表时间：
2022-02-13
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Al Shaer D;Al Musaimi O;Albericio F;de la Torre BG
通讯作者：
de la Torre BG
影响因子：
4.1
作者：
Asberg, Dennis;Weinmann, Annika Langborg;Fornstedt, Torgny
通讯作者：
Fornstedt, Torgny
DOI：
10.1016/0006-3002(50)90049-7
发表时间：
1950-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BATESMITH, EC;WESTALL, RG
通讯作者：
WESTALL, RG
影响因子：
7.4
作者：
Krokhin, Oleg V.;Ying, Stephen;Wilkins, John A.
通讯作者：
Wilkins, John A.