Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study.
Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study.
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布洛芬对脑的影响：一项随机，安慰剂对照的剂量反应探索性研究。
DOI：
10.1016/j.bpsc.2018.05.002
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Paulus MP
中科院分区：
文献类型：
--
作者：
Le TT;Kuplicki R;Yeh HW;Aupperle RL;Khalsa SS;Simmons WK;Paulus MP
一个人的大脑的年龄可以使用整个大脑的形态变化的总测量从结构性大脑图像中估计。脑年龄差距估计（BrainAGE）得分计算为内核估计的脑年龄和实际年龄之间的差异。在这项探索性研究中，我们研究了BrainAGE测量的应用，以确定药物对脑形态的潜在新作用。在一项双盲、交叉研究中，二十名健康参与者（23-47岁）在服用安慰剂或200或600 mg布洛芬后45分钟完成了三次结构磁共振成像扫描。来自480名健康参与者样本的外部衍生BrainAGE模型用于检查布洛芬对健康个体暂时神经解剖学变化的急性影响。BrainAGE模型为每个参与者提供了年龄预测，估计年龄和实际年龄之间的平均绝对误差为6.7岁。BrainAGE的组内相关系数为0.96。与安慰剂相比，200和600 mg布洛芬分别使BrainAGE显著降低1.18和1.15年（p <0.05）。经过训练的BrainAGE模型将内侧前额叶皮层确定为最强的年龄预测器。BrainAGE是一个潜在的有用的结构来检查治疗药物的神经作用。Iceland暂时减少BrainAGE约1年，这可能是由于其急性抗炎作用。
The age of a person’s brain can be estimated from structural brain images using an aggregate measure of variation in morphology across the whole brain. The brain age gap estimation (BrainAGE) score is computed as the difference between kernel-estimated brain age and chronological age. In this exploratory study, we investigated the application of the BrainAGE measure to identify potential novel effects of pharmacological agents on brain morphology. Twenty healthy participants (23–47 years of age) completed three structural magnetic resonance imaging scans 45 minutes after administration of placebo or 200 or 600 mg of ibuprofen in a double-blind, crossover study. An externally derived BrainAGE model from a sample of 480 healthy participants was used to examine the acute effect of ibuprofen on temporary neuroanatomical changes in healthy individuals. The BrainAGE model produced age prediction for each participant with a mean absolute error of 6.7 years between the estimated and chronological age. The intraclass correlation coefficient for BrainAGE was 0.96. Relative to placebo, 200 and 600 mg of ibuprofen significantly decreased BrainAGE by 1.18 and 1.15 years, respectively (p < .05). The trained BrainAGE model identified the medial prefrontal cortex to be the strongest age predictor. BrainAGE is a potentially useful construct to examine neurological effects of therapeutic drugs. Ibuprofen temporarily reduces BrainAGE by approximately 1 year, which is likely due to its acute anti-inflammatory effects.
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影响因子：
5.7
作者：
Franke, Katja;Ziegler, Gabriel;Gaser, Christian
通讯作者：
Gaser, Christian
DOI：
10.1016/j.bbi.2015.06.001
发表时间：
2015-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Haapakoski R;Mathieu J;Ebmeier KP;Alenius H;Kivimäki M
通讯作者：
Kivimäki M
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
9.9
作者：
Gao, Xiang;Chen, Honglei;Ascherio, Alberto
通讯作者：
Ascherio, Alberto
影响因子：
4.8
作者：
Franke K;Gaser C;Manor B;Novak V
通讯作者：
Novak V