Advanced BrainAGE in older adults with type 2 diabetes mellitus.
Advanced BrainAGE in older adults with type 2 diabetes mellitus.
复制标题
DOI：
10.3389/fnagi.2013.00090
复制
发表时间：
2013
影响因子：
4.8
通讯作者：
Novak V
中科院分区：
文献类型：
--
作者：
Franke K;Gaser C;Manor B;Novak V
衰老会改变大脑结构和功能，糖尿病可能会加速这一过程。本研究探讨了2型糖尿病对个体脑衰老的影响，以及个体脑衰老、危险因素和功能指标之间的关系。为了区分偏离正常脑衰老的脑萎缩模式，我们使用了新颖的BrainAGE方法，该方法通过将已建立的核回归方法应用于解剖脑磁共振图像（MRI）来确定整个脑内复杂的多维衰老模式。“脑年龄差距估计”（BrainAGE）得分被计算为实足年龄和预估脑年龄之间的差异。185名受试者（98名2型糖尿病患者）在3Tesla完成了MRI、实验室和临床评估。25名受试者（12名2型糖尿病患者）也在3.8±1.5年后完成了随访。DM受试者的脑年龄估计比其实足年龄大4.6±7.2岁（p = 0.0001），而对照组的脑年龄估计与实足年龄相似。与基线相比，糖尿病受试者的平均BrainAGE评分每随访一年增加0.2岁（p = 0.034），而对照组的BrainAGE评分在基线和随访期间没有变化。在基线，在所有受试者中，较高的BrainAGE分数与吸烟和饮酒较多、较高的肿瘤坏死因子α (TNFα)水平、较低的语言流畅性分数和更严重的抑郁症有关。在糖尿病组中，较高的BrainAGE评分与较长的糖尿病病程（r = 0.31, p = 0.019）和较高的空腹血糖水平（r = 0.34, p = 0.025）相关。总之，2型糖尿病与反映衰老的大脑结构变化独立相关。因此，BrainAGE方法可以作为检测与2型糖尿病相关的脑衰老异常模式的临床相关生物标志物。
Aging alters brain structure and function and diabetes mellitus (DM) may accelerate this process. This study investigated the effects of type 2 DM on individual brain aging as well as the relationships between individual brain aging, risk factors, and functional measures. To differentiate a pattern of brain atrophy that deviates from normal brain aging, we used the novel BrainAGE approach, which determines the complex multidimensional aging pattern within the whole brain by applying established kernel regression methods to anatomical brain magnetic resonance images (MRI). The “Brain Age Gap Estimation” (BrainAGE) score was then calculated as the difference between chronological age and estimated brain age. 185 subjects (98 with type 2 DM) completed an MRI at 3Tesla, laboratory and clinical assessments. Twenty-five subjects (12 with type 2 DM) also completed a follow-up visit after 3.8 ± 1.5 years. The estimated brain age of DM subjects was 4.6 ± 7.2 years greater than their chronological age (p = 0.0001), whereas within the control group, estimated brain age was similar to chronological age. As compared to baseline, the average BrainAGE scores of DM subjects increased by 0.2 years per follow-up year (p = 0.034), whereas the BrainAGE scores of controls did not change between baseline and follow-up. At baseline, across all subjects, higher BrainAGE scores were associated with greater smoking and alcohol consumption, higher tumor necrosis factor alpha (TNFα) levels, lower verbal fluency scores and more severe deprepession. Within the DM group, higher BrainAGE scores were associated with longer diabetes duration (r = 0.31, p = 0.019) and increased fasting blood glucose levels (r = 0.34, p = 0.025). In conclusion, type 2 DM is independently associated with structural changes in the brain that reflect advanced aging. The BrainAGE approach may thus serve as a clinically relevant biomarker for the detection of abnormal patterns of brain aging associated with type 2 DM.
登录
查看更多内容
影响因子：
5.7
作者：
Franke, Katja;Ziegler, Gabriel;Gaser, Christian
通讯作者：
Gaser, Christian
影响因子：
16.2
作者：
de Bresser J;Tiehuis AM;van den Berg E;Reijmer YD;Jongen C;Kappelle LJ;Mali WP;Viergever MA;Biessels GJ;Utrecht Diabetic Encephalopathy Study Group
通讯作者：
Utrecht Diabetic Encephalopathy Study Group
影响因子：
2.8
作者：
ARAKI, Y;NOMURA, M;NAKAMURA, H
通讯作者：
NAKAMURA, H
影响因子：
3.1
作者：
Harrison, JE;Buxton, P;Wise, R
通讯作者：
Wise, R
DOI：
10.1024/1662-9647/a000074
发表时间：
2012-12-01
影响因子：
1
作者：
Franke, Katja;Gaser, Christian
通讯作者：
Gaser, Christian