Quantitative evaluation of contrast-enhanced ultrasonography in the diagnosis of chronic ischemic renal disease in a dog model.
Quantitative evaluation of contrast-enhanced ultrasonography in the diagnosis of chronic ischemic renal disease in a dog model.
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DOI：
10.1371/journal.pone.0070337
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Dong Y;Wang W;Cao J;Fan P;Lin X
本可行性研究的目的是在慢性缺血性肾病（CIRD）犬模型中前瞻性地探索实时超声造影（CEUS）可以定量评价肾皮质早期灌注变化的假设。在本动物护理和使用委员会批准的研究中，在健康犬（10.0 - 12.0 kg，n = 5）中，通过手术将Ameroid环缩窄器放置在右肾动脉远端部分来进行CIRD模型。 右肾灌注的CEUS监测通过静脉内推注0.6ml六氟化硫填充的微泡（SonoVue; Braviens S.P.A.，意大利米兰）术后每周一次。使用商业定量软件（Q-LAB第6版; Philips Medical Systems，博瑟尔，WA，USA）测量肾皮质中上升曲线（A）和下降曲线（α）的斜率、曲线下面积（AUC）、推导峰强度（DPI）和达峰时间（TTP）。比较CEUS与血清尿素氮（BUN）、肌酐（SCr）的敏感性。随着CIRD的进展，犬肾脏CEUS曲线呈延迟性增强和灌注。术后4周DPI和TTP变化最早，分别为13.04±2.71 ~ 15.58± 4.75dB和9.03±2.01 ~ 10.62± 6.04sec（P<0.05）。CEUS可早期显示CIRD的血流灌注改变。
The aim of this feasibility study was to prospectively explore in a dog model of chronic ischemic renal disease (CIRD) the hypothesis that real-time contrast-enhanced ultrasonography (CEUS) can quantitatively evaluate the early perfusion changes of renal cortex. In this animal care and use committee-approved study, the model of CIRD was carried out in healthy dogs (10.0∼12.0 kg, n = 5), by placing the Ameroid ring constrictors on the distal portion of right renal artery through operation. CEUS monitoring of right kidney perfusion was performed by intravenous bolus injection of 0.6 ml Sulfur hexafluoride filled microbubbles (SonoVue; Bracco S.P.A., Milan, Italy) every week after operation. The slope rate of ascending curve (A) and descending curve (α), area under curve (AUC), derived peak intensity (DPI), and time to peak (TTP) were measured in renal cortex using commercial quantification software (Q-LAB version 6; Philips Medical Systems, Bothell,WA,USA). The sensitivity of CEUS was compared with blood serum urea nitrogen (BUN) and serum creatinine (SCr) level. With the progression of CIRD, dogs showed delayed enhancement and perfusion in renal CEUS curve. Earliest significant changes happened 4 weeks after operation on DPI and TTP which changed from 13.04±2.71 to 15.58±4.75 dB and 9.03±2.01 to 10.62±6.04 sec, respectively (P<.05). CEUS can display the perfusion changes of CIRD in the early period.
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DOI：
10.1007/s00259-010-1537-7
发表时间：
2010-08-01
影响因子：
9.1
作者：
Cosgrove, David;Lassau, Nathalie
通讯作者：
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影响因子：
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影响因子：
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