Matrix metalloproteinases: old dogs with new tricks.

Matrix metalloproteinases: old dogs with new tricks.
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DOI:
10.1186/gb-2003-4-6-216
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发表时间:
2003
期刊:
影响因子:
12.3
通讯作者:
Apte SS
Apte SS
中科院分区:
生物学1区
文献类型:
--
作者:
Somerville RP;Oblander SA;Apte SS

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以前人们认为基质金属蛋白酶家族只降解细胞外基质的成分,但随着非细胞外基质分子也是底物的发现,这种观点发生了变化。人类基质金属蛋白酶家族包括23种酶,它们参与许多生物过程和疾病。以前人们认为这些酶只降解细胞外基质的成分,但这种观点随着发现非细胞外基质分子也是底物而改变。
It was previously thought that the matrix metalloproteinase family acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates. The matrix metalloproteinase family in humans comprises 23 enzymes, which are involved in many biological processes and diseases. It was previously thought that these enzymes acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates.
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