Age-related reduction in single muscle fiber calcium sensitivity is associated with decreased muscle power in men and women.
Age-related reduction in single muscle fiber calcium sensitivity is associated with decreased muscle power in men and women.
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DOI：
10.1016/j.exger.2017.12.007
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发表时间：
2018-03
影响因子：
3.9
通讯作者：
Miller MS
中科院分区：
文献类型：
--
作者：
Straight CR;Ades PA;Toth MJ;Miller MS
Age-related declines in human skeletal muscle performance may be caused, in part, by decreased responsivity of muscle fibers to calcium (Ca2+). This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range of Ca2+ concentrations in 11 young (24.1 ± 1.1 years) and 10 older (68.8 ± 0.8 years) men and women. The normalized pCa-force curve shifted rightward with age, leading to decreased activation threshold (pCa10) and/or Ca2+ sensitivity (pCa50) for all MHC isoforms examined. In older adults, the slope of the pCa-force curve was unchanged in MHC I-containing fibers (I, I/IIA), but was steeper in MHC II-containing fibers (IIA, IIAX), indicating greater cooperativity compared to young adults. At sub-maximal [Ca2+], specific force was reduced in MHC I-containing fibers, but was minimally decreased in MHC IIA fibers as older adults produced greater specific forces at high [Ca2+] in these fibers. Lessor pCa50 in MHC I fibers independently predicted reduced isokinetic knee extensor power across a range of contractile velocities, suggesting that the Ca2+ response of slow-twitch fibers contributes to whole muscle dysfunction. Our findings show that aging attenuates Ca2+ responsiveness across fiber types and that these cellular alterations may lead to age-related reductions in whole muscle power output.
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影响因子：
5.5
作者：
D'Antona, G;Pellegrino, MA;Bottinelli, R
通讯作者：
Bottinelli, R
影响因子：
2.7
作者：
Gilliver, S. F.;Degens, H.;Jones, D. A.
通讯作者：
Jones, D. A.
影响因子：
3.3
作者：
FRONTERA, WR;HUGHES, VA;EVANS, WJ
通讯作者：
EVANS, WJ
影响因子：
2.4
作者：
Chen, Xuefeng;Sanchez, Gabriel N.;Delp, Scott L.
通讯作者：
Delp, Scott L.
DOI：
10.1093/gerona/55.4.m192
发表时间：
2000-04-01
影响因子：
5.1
作者：
Foldvari, M;Clark, M;Singh, MAF
通讯作者：
Singh, MAF