In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition.
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition.
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DOI：
10.1038/s41467-020-18841-7
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发表时间：
2020-10-07
影响因子：
16.6
通讯作者：
Park JA
中科院分区：
文献类型：
--
作者：
Mitchel JA;Das A;O'Sullivan MJ;Stancil IT;DeCamp SJ;Koehler S;Ocaña OH;Butler JP;Fredberg JJ;Nieto MA;Bi D;Park JA
上皮-间充质转化（EMT）和非干扰性转化（UJT）各自包含细胞迁移、可塑性和重塑的通道，但这些核心程序在多大程度上是不同的、重叠的或相同的仍然不确定。在这里，我们在分化的原代人支气管上皮细胞中触发部分EMT（pEMT）或UJT。在触发UJT后，细胞-细胞连接、顶端-基底极性和屏障功能保持完整，细胞伸长并排列成合作的迁移包，EMT的间充质标志物保持不明显。在触发pEMT之后，UJT对pEMT的这些和其他度量偏离。一个计算模型属性的pEMT的影响主要是减少连接紧张，但属性的UJT主要是增强细胞推进。通过UJT和pEMT独立、顺序或相互作用的作用，那些受到发育、损伤或疾病的组织被赋予了丰富的细胞迁移、可塑性、自我修复和再生机制。在修复、发展或癌症转移期间，上皮细胞可以通过部分或全部上皮向间质转化（EMT）而变得迁移。在这里，作者报告说，分化的上皮集体可能会经历合作和集体迁移，而没有证据表明部分EMT通过一个unjamming过渡（UJT）。
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) or UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier function remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of EMT remain unapparent. After triggering pEMT these and other metrics of UJT versus pEMT diverge. A computational model attributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular migration, plasticity, self-repair, and regeneration. During repair, development, or cancer metastasis, epithelial cells can become migratory through partial or full epithelial to mesenchymal transition (EMT). Here, the authors report that differentiated epithelial collectives may undergo cooperative and collective migration without evidence of partial EMT through an unjamming transition (UJT).
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EMT亚型影响上皮可塑性和细胞迁移模式。
影响因子：
11.8
作者：
Aiello NM;Maddipati R;Norgard RJ;Balli D;Li J;Yuan S;Yamazoe T;Black T;Sahmoud A;Furth EE;Bar-Sagi D;Stanger BZ
通讯作者：
Stanger BZ
影响因子：
19
作者：
Diz-Muñoz A;Fletcher DA;Weiner OD
通讯作者：
Weiner OD
影响因子：
7.3
作者：
Barriga EH;Mayor R
通讯作者：
Mayor R
影响因子：
4.3
作者：
Chiou, Kevin K.;Hufnagel, Lars;Shraiman, Boris I.
通讯作者：
Shraiman, Boris I.
影响因子：
6.9
作者：
Adams, David C.;Miller, Alyssa J.;Suter, Melissa J.
通讯作者：
Suter, Melissa J.