An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study.
An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study.
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DOI：
10.1007/s00415-010-5756-4
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发表时间：
2011-02
影响因子：
6
通讯作者：
Dippel DW
中科院分区：
文献类型：
--
作者：
den Hertog HM;van der Worp HB;van Gemert HM;Algra A;Kappelle LJ;van Gijn J;Koudstaal PJ;Dippel DW
约三分之一的患者在中风发作后第一天出现体温过低或发烧，并且与不良预后相关。然而，这种关联的时间概况尚未确定。我们的目的是评估入院时的体温以及入院后 24 小时内的体温变化与功能结果和死亡之间的关系。我们分析了 1,332 名中风发病 12 小时内入院的患者的数据。一方面，入院时的体温或入院后 24 小时内的体温变化（根据入院时的体温进行调整）与 3 个月时的不良结果（死亡或改良的Rankin 量表评分 >2）之间的关系，以体温每升高 1.0°C 的比值比表示。使用多元逻辑回归模型对潜在的混杂因素进行了调整。未发现入院体温与不良结局（aOR 1.06；95% CI 0.85–1.32）和死亡（aOR 1.23；95% CI 0.95–1.60）之间存在相关性。相比之下，中风发病后前 24 小时内体温升高与预后不良（aOR 1.30；95% CI 1.05–1.63）和死亡（aOR 1.51；95% CI 1.15–1.98）相关。早期体温升高而非入院时体温升高是急性卒中患者预后不良的危险因素。
Subfebrile temperature or fever is present in about a third of patients on the first day after stroke onset and is associated with poor outcome. However, the temporal profile of this association is not well established. We aimed to assess the relationship between body temperature on admission as well as the change in body temperature from admission to 24 h thereafter and functional outcome and death. We analyzed data of 1,332 patients admitted within 12 h of stroke onset. The relation between body temperature on admission or the change in body temperature from admission to 24 h thereafter (adjusted for body temperature on admission) on the one hand and unfavorable outcome (death, or a modified Rankin Scale score >2) at 3 months on the other were expressed as odds ratio per 1.0°C increase in body temperature. Adjustments for potential confounders were made with a multiple logistic regression model. No relation was found between admission body temperature and poor outcome (aOR 1.06; 95% CI 0.85–1.32) and death (aOR 1.23; 95% CI 0.95–1.60). In contrast, increased body temperature in the first 24 h after stroke onset was associated with poor outcome (aOR 1.30; 95% CI 1.05–1.63) and death (aOR 1.51; 95% CI 1.15–1.98). An early rise in body temperature rather than high body temperature on admission is a risk factor for unfavorable outcome in patients with acute stroke.
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影响因子：
48
作者：
den Hertog, Heleen M.;van der Worp, H. Bart;Dippel, Diederik W. J.
通讯作者：
Dippel, Diederik W. J.
影响因子：
8.3
作者：
VANSWIETEN, JC;KOUDSTAAL, PJ;VANGIJN, J
通讯作者：
VANGIJN, J
影响因子：
3.5
作者：
Ernon, L.;Schrooten, M.;Thijs, V.
通讯作者：
Thijs, V.
影响因子：
8.3
作者：
BROTT, T;ADAMS, HP;WALKER, M
通讯作者：
WALKER, M
影响因子：
8.3
作者：
Hajat, C;Hajat, S;Sharma, P
通讯作者：
Sharma, P