Time-Dependent Change in Cartilage Repair Tissue Evaluated by Magnetic Resonance Imaging up to 2 years after Atelocollagen-Assisted Autologous Cartilage Transplantation: Data from the CaTCh Study.
Time-Dependent Change in Cartilage Repair Tissue Evaluated by Magnetic Resonance Imaging up to 2 years after Atelocollagen-Assisted Autologous Cartilage Transplantation: Data from the CaTCh Study.
复制标题
用磁共振成像评估自体软骨移植后2年内软骨修复组织随时间的变化：来自CATCH研究的数据。
DOI：
10.1177/19476035221109227
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发表时间：
2022-07
期刊：
影响因子：
2.8
通讯作者：
Sasho, Takahisa
中科院分区：
文献类型：
--
作者：
Shinohara, Masashi;Akagi, Ryuichiro;Watanabe, Atsuya;Kato, Yuki;Sato, Yusuke;Morikawa, Tsuguo;Iwasaki, Junichi;Nakagawa, Koichi;Akatsu, Yorikazu;Ohtori, Seiji;Sasho, Takahisa
阐明去端胶原辅助自体软骨细胞植入（ACI）后基于磁共振成像（MRI）的形态学和定性结局的时间过程，并分析关节镜和基于MRI的评估之间的相关性。我们纳入了一项多中心注册研究（CaTCh [千叶Carbohydrate治疗]研究）中的ACI受试者。植入后6个月、12个月和24个月通过MRI进行形态学（软骨修复组织的三维磁共振观察：3D-MOCART、MOCART2.0）和定性评估（T2和T1 rho标测）。计算整体T2和T1 rho指数（修复组织中的T2和T1 rho除以正常软骨中的T2和T1 rho）。分别在植入后12个月和24个月对4例和15例膝关节进行了关节镜二次探查评估。12个月的3D-MOCART观察到患者显著改善，但有些患者早在6个月时就出现了软骨下骨退变。6个月至24个月期间，MOCART 2.0从57.5改善至71.3（P = 0.02）。总T2指数在6个月至24个月期间从1.7降至1.2（P < 0.001）。6个月至24个月期间，总体T1 rho指数从1.5降至1.3（P = 0.004）。在12个月和24个月时，分别有86%和93%的病变达到了正常或接近正常的ICRS-CRA（由国际软骨修复学会开发的软骨修复评估量表）等级。更好的ICRS-CRA等级对应于更好的MOCART2.0，T2和T1 rho值无趋势。Atelocollagen辅助ACI改善了基于MRI的形态学和定性结局，直至术后24个月，通过关节镜评估，大多数病变均达到正常或接近正常等级。MRI评估可能是关节镜评估的替代方法。
To elucidate the time course of magnetic resonance imaging (MRI)–based morphological and qualitative outcomes after an atelocollagen-assisted autologous chondrocyte implantation (ACI) and to analyze the correlation between arthroscopic and MRI-based assessment. We included ACI recipients from a multicenter registration study (CaTCh [Cartilage Treatment in Chiba] study). Morphological (3-dimensional magnetic resonance observation of cartilage repair tissue: 3D-MOCART, MOCART2.0) and qualitative assessment (T2- and T1rho-mapping) by MRI were conducted at 6, 12, and 24 months post-implantation. Global T2 and T1rho indices (T2 and T1rho in repair tissue divided by T2 and T1rho in normal cartilage) were calculated. Arthroscopic second-look assessment was performed in 4 and 15 knees at 12 and 24 months post-implantation, respectively. The 3D-MOCART over 12 months witnessed significant patient improvement, but some presented subchondral bone degeneration as early as 6 months. The MOCART2.0 improved from 57.5 to 71.3 between 6 and 24 months (P = 0.02). The global T2 index decreased from 1.7 to 1.2 between 6 and 24 months (P < 0.001). The global T1rho index decreased from 1.5 to 1.3 between 6 and 24 months (P = 0.004). Normal or nearly normal ICRS-CRA (cartilage repair assessment scale developed by the International Cartilage Repair Society) grades were achieved in 86% and 93% of the lesions at 12 and 24 months, respectively. Better ICRS-CRA grade corresponded to better MOCART2.0, with no trend in the T2 and T1rho values. Atelocollagen-assisted ACI improved the MRI-based morphological and qualitative outcomes until 24 months post-surgery, and normal or nearly normal grades were achieved in most lesions by arthroscopic assessment. MRI assessment may be an alternative to arthroscopic assessment.
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影响因子：
2.8
作者：
Schreiner MM;Raudner M;Marlovits S;Bohndorf K;Weber M;Zalaudek M;Röhrich S;Szomolanyi P;Filardo G;Windhager R;Trattnig S
通讯作者：
Trattnig S
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4.8
作者：
Pestka, Jan M.;Bode, Gerrit;Niemeyer, Philipp
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Niemeyer, Philipp
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4.8
作者：
Niethammer, Thomas R.;Safi, Elem;Mueller, Peter E.
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Mueller, Peter E.
影响因子：
3.8
作者：
Adachi, Nobuo;Ochi, Mitsuo;Iwasa, Junji
通讯作者：
Iwasa, Junji
影响因子：
7
作者：
Domayer, S. E.;Kutscha-Lissberg, F.;Trattnig, S.
通讯作者：
Trattnig, S.