Estrogen-Related Receptors in Breast Cancer and Prostate Cancer.
Estrogen-Related Receptors in Breast Cancer and Prostate Cancer.
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DOI：
10.3389/fendo.2015.00083
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发表时间：
2015
影响因子：
5.2
通讯作者：
Inoue S
中科院分区：
文献类型：
--
作者：
Misawa A;Inoue S
雌激素信号通路与乳腺癌和前列腺癌的发展有关。各种研究集中在由雌激素相关受体（ERRs）介导的其他信号通路上。雌激素受体（ER）是与经典雌激素受体（ER）具有高度同源性的组成型活性受体。然而，它们不结合雌激素，而ER结合。ERR参与导致癌症发展的替代途径的发展，并且被认为是治疗对常规疗法无应答的乳腺癌和前列腺癌的潜在治疗靶点。在这篇综述中，我们首先介绍了一般的结构特征的错误反应。然后，我们专注于乳腺癌和前列腺癌，这是主要的乳腺癌依赖性癌症，并总结了最近的进展，阐明这两种类型的恶性肿瘤中的每个ERR的参与。
Estrogen-signaling pathways are implicated in the development of breast cancer and prostate cancer. Various studies have focused on additional signaling pathways, mediated by estrogen-related receptors (ERRs). ERRs are constitutively active receptors that share a high degree of homology with the classical estrogen receptors (ERs). However, they do not bind to estrogen, while ERs do. ERRs are involved in the development of alternative pathways that lead to the development of cancer and are regarded as potential therapeutic targets for the treatment of breast cancer and prostate cancer that do not respond to conventional therapies. In this review, we first present general structural features of ERRs. Then, we focus on breast cancer and prostate cancer, which are primarily hormone-dependent cancers, and summarizes recent progress in elucidating the involvement of each ERR in these two types of malignancies.
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影响因子：
8
作者：
Cai, Q.;Lin, T.;Kamarajugadda, S.;Lu, J.
通讯作者：
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影响因子：
21.3
作者：
Feng, Bo;Jiang, Jianming;Ng, Huck-Hui
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Mangelsdorf, David J.
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Dufour, Catherine R.;Wilson, Brian J.;Giguere, Vincent
通讯作者：
Giguere, Vincent
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作者：
Barry, JB;Laganière, J;Giguère, V
通讯作者：
Giguère, V