Radial arm maze deficits in rats exposed to alcohol during midgestation

Radial arm maze deficits in rats exposed to alcohol during midgestation
复制标题

妊娠中期暴露于酒精的大鼠的桡臂迷宫缺陷

DOI:
--
复制
发表时间:
1994
期刊:
Psychobiology
影响因子:
--
通讯作者:
R. Berman
R. Berman
中科院分区:
--
文献类型:
--
作者:
J. Hall;M. Church;R. Berman

文献摘要

参考文献

被引文献

相似文献

在出生前暴露于酒精的幼龄和成年大鼠中检查了径向臂迷宫性能,时间相对较短,即孕7-13天。当幼年动物(26日龄)在径向臂迷宫训练,酒精暴露的后代作出了显着更多的错误比动物在营养或即兴对照组在第二和第三块的试验。然而,在训练结束时,酒精暴露的后代在与对照动物相同的水平上执行任务。当这些动物在90日龄时重新测试时,径向臂迷宫性能与对照动物相当,表明一旦获得,径向臂迷宫性能在产前暴露于酒精的动物中保留到成年。当在成年期(90日龄)开始进行放射臂迷宫训练时,产前暴露于酒精的大鼠表现出放射臂迷宫性能不足。因此,早期的行为经验可能有助于治疗产前酒精中毒引起的学习和记忆缺陷。
Radial arm maze performance was examined in juvenile and adult rats prenatally exposed to alcohol for the relatively brief period of Gestational Days 7–13. When juvenile animals (26 days of age) were trained in the radial arm maze, alcohol-exposed offspring made significantly more errors than did animals in either nutritional or ad-lib control groups during the second and third blocks of trials. However, by the end of training, alcohol-exposed offspring performed the task at the same level as control animals. When these animals were retested at 90 days of age, radial arm maze performance was comparable to that of control animals, suggesting that once acquired, radial arm maze performance is retained into adulthood in animals prenatally exposed to alcohol. When radial arm maze training began in adulthood (90 days of age), rats prenatally exposed to alcohol demonstrated deficient radial arm maze performance. Thus, early behavioral experience may be useful for treating prenatal-alcohol-exposure-induced deficits in learning and memory.
围产期酒精暴露的营养问题。
DOI: --
发表时间: 1984
期刊: Neurobehavioral toxicology and teratology
影响因子: --
作者:
Weinberg,J
通讯作者: Weinberg,J
产前酒精暴露后大鼠的脑代谢变化:脱氧葡萄糖研究。
DOI: 10.1111/j.1530-0277.1986.tb05607.x
发表时间: 1986
期刊: Alcoholism, clinical and experimental research
影响因子: --
作者:
Vingan,RD;Dow-Edwards,DL;Riley,EP
通讯作者: Riley,EP
优先酒精胚胎病:流质饮食的影响。
DOI: --
发表时间: 1992
期刊: Laboratory animal science
影响因子: --
作者:
Mankes,RF;Battles,AH;LeFevre,R;vanderHoeven,T;Glick,SD
通讯作者: Glick,SD
产前酒精暴露对大鼠的长期行为影响。
DOI: 10.1111/j.1530-0277.1990.tb01225.x
发表时间: 1990
期刊: Alcoholism, clinical and experimental research
影响因子: --
作者:
Riley,EP
通讯作者: Riley,EP
产前酒精暴露会改变海马切片电生理学。
DOI: 10.1016/0741-8329(90)90040-j
发表时间: 1990
期刊: Alcohol (Fayetteville, N.Y.)
影响因子: --
作者:
Tan,SE;Berman,RF;Abel,EL;Zajac,CS
通讯作者: Zajac,CS