Accelerated in vitro release testing of implantable PLGA microsphere/PVA hydrogel composite coatings.
Accelerated in vitro release testing of implantable PLGA microsphere/PVA hydrogel composite coatings.
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DOI：
10.1016/j.ijpharm.2011.10.020
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发表时间：
2012-01-17
影响因子：
5.8
通讯作者：
Burgess, Diane J.
中科院分区：
文献类型：
--
作者：
Shen, Jie;Burgess, Diane J.
关键词：
Dexamethasone loaded poly(lactic-co-glycolic acid) (PLGA) microsphere/PVA hydrogel composites have been investigated as an outer drug-eluting coating for implantable devices such as glucose sensors to counter negative tissue responses to implants. The objective of this study was to develop a discriminatory, accelerated in vitro release testing method for this drug-eluting coating using United States Pharmacopeia (USP) apparatus 4. Polymer degradation and drug release kinetics were investigated under “real-time” and accelerated conditions (i.e. extreme pH, hydro-alcoholic solutions and elevated temperatures). Compared to “real-time” conditions, the initial burst and lag phases were similar using hydro-alcoholic solutions and extreme pH conditions, while the secondary apparent zero-order release phase was slightly accelerated. Elevated temperatures resulted in a significant acceleration of dexamethasone release. The accelerated release data were able to predict “real-time” release when applying the Arrhenius equation. Microsphere batches with faster and slower release profiles were investigated under “real-time” and elevated temperature (60°C) conditions to determine the discriminatory ability of the method. The results demonstrated both the feasibility and the discriminatory ability of this USP apparatus 4 method for in vitro release testing of drug loaded PLGA microsphere/PVA hydrogel composites. This method may be appropriate for similar drug/device combination products and drug delivery systems.
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影响因子：
14
作者：
Norton, LW;Tegnell, E;Reichert, WM
通讯作者：
Reichert, WM
影响因子：
4.6
作者：
Kamberi, Marika;Nayak, Sushma;Feder, Debra
通讯作者：
Feder, Debra
影响因子：
5.8
作者：
Bhardwaj, Upkar;Sura, Radhakrishana;Burgess, Diane J.
通讯作者：
Burgess, Diane J.
影响因子：
4.5
作者：
Galeska, I;Kim, TK;Burgess, DJ
通讯作者：
Burgess, DJ
影响因子：
5.8
作者：
Klose, D.;Siepmann, F.;Siepmann, J.
通讯作者：
Siepmann, J.