Amphetamine-induced striatal dopamine release in schizotypal personality disorder.
Amphetamine-induced striatal dopamine release in schizotypal personality disorder.
复制标题
安非他明诱导精神分裂型人格障碍纹状体多巴胺释放。
DOI：
10.1007/s00213-020-05561-5
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发表时间：
2020
影响因子：
3.4
通讯作者：
Abi-Da
中科院分区：
文献类型：
--
作者：
Thompson,JudyL;Rosell,DanielR;Slifstein,Mark;Xu,Xiaoyan;Rothstein,EthanG;Modiano,YosefaA;Kegeles,LawrenceS;Koenigsberg,HaroldW;New,AntoniaS;Hazlett,ErinA;McClure,MargaretM;Perez-Rodriguez,MMercedes;Siever,LarryJ;Abi-Da
RationalePrevious research has suggested that schizotypal personality disorder (SPD), a condition that shares clinical and cognitive features with schizophrenia, may be associated with elevated striatal dopamine functioning; however, there are no published studies of dopamine release within subregions of the striatum in SPD.ObjectivesTo characterize dopamine release capacity in striatal subregions and its relation to clinical and cognitive features in SPD.MethodsWe used positron emission tomography with [11C]raclopride and an amphetamine challenge to measure dopamine D2-receptor availability (binding potential, BPND), and its percent change post-amphetamine (∆BPND) to index amphetamine-induced dopamine release, in subregions of the striatum in 16 SPD and 16 healthy control participants. SPD participants were evaluated with measures of schizotypal symptom severity and working memory.ResultsThere were no significant group differences in BPNDor ∆BPNDin any striatal subregion or whole striatum. Among SPD participants, cognitive-perceptual symptoms were associated at trend level with ∆BPNDin the ventral striatum, and disorganized symptoms were significantly negatively related to ∆BPNDin several striatal subregions.ConclusionsIn contrast to previous findings, SPD was not associated with elevated striatal dopamine release. However, in SPD, there was a moderate positive association between ventral striatal dopamine release and severity of cognitive-perceptual symptoms, and negative associations between striatal dopamine release and severity of disorganized symptoms. Future larger scale investigations that allow for the separate examination of subgroups of participants based on clinical presentation will be valuable in further elucidating striatal DA functioning in SPD.
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影响因子：
6.6
作者：
Woods, Scott W.;Addington, Jean;McGlashan, Thomas H.
通讯作者：
McGlashan, Thomas H.
影响因子：
17.7
作者：
Yoon, Jong H.;Minzenberg, Michael J.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
DOI：
10.1097/00004647-199601000-00005
发表时间：
1996-01-01
影响因子：
6.3
作者：
Lammertsma, AA;Bench, CJ;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ
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影响因子：
3
作者：
Jijun Wang;H. Miyazato;H. Hokama;K. Hiramatsu;T. Kondo
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T. Kondo
影响因子：
11.3
作者：
H. Noguchi;H. Hori;H. Kunugi
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H. Noguchi;H. Hori;H. Kunugi