Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population.
Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population.
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DOI：
10.3389/fimmu.2020.561142
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发表时间：
2020
影响因子：
7.3
通讯作者：
Yavo W
中科院分区：
文献类型：
--
作者：
Amiah MA;Ouattara A;Okou DT;N'Guetta SA;Yavo W
恶性疟原虫的反复感染导致体液反应，可以减轻疾病症状并防止临床疟疾的发展。这种体液应答的主要机制是免疫球蛋白G（IgG）直接与寄生虫结合，从而使其中和。然而，抗体本身的作用并不总是足以从生物体中消除病原体。参与识别IgG的一个关键要素是Fc γ受体家族，IgG在破坏负责传播疟疾的寄生虫中起关键作用。这些受体在免疫细胞的表面上表达。在编码这些受体的基因中已经检测到几种多态性，这些多态性与不同人群对疟疾的易感性或抗性有关。在这篇综述中，我们描述了Fc γ受体家族内的多态性，以及这些变异对宿主感染反应的影响，并为设计有效的疟疾疫苗提供了新的视角。
Repeated infections by Plasmodium falciparum result in a humoral response that could reduce disease symptoms and prevent the development of clinical malaria. The principal mechanism underlying this humoral response is that immunoglobulin G (IgG) binds directly to the parasites, thus causing their neutralization. However, the action of antibodies alone is not always sufficient to eliminate pathogens from an organism. One key element involved in the recognition of IgG that plays a crucial role in the destruction of the parasites responsible for spreading malaria is the family of Fc gamma receptors. These receptors are expressed on the surface of immune cells. Several polymorphisms have been detected in the genes encoding these receptors, associated with susceptibility or resistance to malaria in different populations. In this review, we describe identified polymorphisms within the family of Fc gamma receptors and the impact of these variations on the response of a host to infection as well as provide new perspectives for the design of an effective vaccine for malaria.
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影响因子：
16.6
作者：
Band, Gavin;Le, Quang Si;Kwiatkowski, Dominic P.
通讯作者：
Kwiatkowski, Dominic P.
影响因子：
6.4
作者：
Adu, Bright;Jepsen, Micha Phill Gronholm;Theisen, Michael
通讯作者：
Theisen, Michael
影响因子：
5
作者：
Andres Perez-Romero, Camilo;Pilar Sanchez, Isaura;Milena Trujillo-Vargas, Claudia
通讯作者：
Milena Trujillo-Vargas, Claudia
影响因子：
45.3
作者：
Bibeau, Frederic;Lopez-Crapez, Evelyne;Boissiere-Michot, Florence
通讯作者：
Boissiere-Michot, Florence
影响因子：
20.3
作者：
Carlsson, LE;Santoso, S;Greinacher, A
通讯作者：
Greinacher, A