Effects of co-infection with Clonorchis sinensis on the sex hormones levels in male patients with chronic hepatitis B.
Effects of co-infection with Clonorchis sinensis on the sex hormones levels in male patients with chronic hepatitis B.
复制标题
华支睾吸虫合并感染对男性慢性乙型肝炎患者性激素水平的影响
DOI：
10.1002/jcla.24663
复制
发表时间：
2022-09
影响因子：
2.7
通讯作者：
Hu, Bo
中科院分区：
文献类型：
--
作者：
Dong, Huimin;Shang, Mei;Luo, Minqi;Chen, Wenya;Hu, Bo
我们评估了合并感染华支睾吸虫的男性B型肝炎患者的性激素水平。本研究共入组136名男性个体，包括27名健康对照、28名单纯感染华支睾吸虫的患者、19名仅慢性B型肝炎患者、18名B型肝炎后肝硬化患者、26名慢性B型肝炎患者合并感染华支睾吸虫，以及18名肝炎后B型肝硬化患者合并感染华支睾吸虫。测定各组血清孕酮（P）、黄体生成素（LH）、雌二醇（E2）、睾酮（T）、催乳素（PRL）、卵泡刺激素（FSH）水平。结果显示，与LC组相比，LC+ C. sinensis共感染组E2升高，T和FSH降低。CHB+华支睾吸虫合并感染患者的E2水平明显高于CHB单一感染患者，但观察到T水平明显较低。与HC组相比，LC组除PRL外，其他各项性激素均显著升高。相比之下，CHB单感染组的E2、T和PRL明显低于HC组。然而，在单一感染中华绒螯蟹的患者和HC之间，性激素水平没有显著差异。这项研究表明，中华绒螯蟹合并感染加重了慢性肝炎和肝硬化阶段HBV患者的性激素紊乱，为疾病预防和治疗的潜在策略提供了证据。我们评估了合并感染华支睾吸虫的男性B型肝炎患者的性激素水平。实验对象分为6组，即健康对照组（HC）、华支睾吸虫组、慢性B型肝炎组（CH B）、肝硬化组（LC）、CH B+华支睾吸虫组、LC+华支睾吸虫组。我们测量并比较了各组的性激素水平。结果发现，中华绒螯蟹合并感染加重了慢性肝炎和肝硬化阶段HBV患者的性激素紊乱，为疾病预防和治疗的潜在策略提供了证据。
We evaluated the levels of sex hormones in male hepatitis B patients co‐infected with Clonorchis sinensis (C. sinensis). A total of 136 male individuals were enrolled in this study, including 27 healthy controls, 28 patients with C. sinensis mono‐infection, 19 patients with only chronic hepatitis B, 18 patients with post‐hepatitis B liver cirrhosis, 26 chronic hepatitis B patients co‐infected with C. sinensis, and 18 post‐hepatitis B liver cirrhosis patients coinfected with C. sinensis. Serum levels of progesterone (P), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), and follicle stimulating hormone (FSH) in these groups were measured. The results showed that compared with the LC group, the LC+ C. sinensis co‐infected group had an increase in E2 but decrease in T and FSH. The levels of E2 in CHB+ C. sinensis co‐infected patients were significantly higher than those in CHB mono‐infected patients, but the significantly lower levels of T were observed. Compared with HCs group, the LC group showed significant increase in all terms of sex hormones, except PRL. By contrast, the CHB mono‐infected group presented an apparent decrease in E2, T, and PRL than the HCs group. However, there were no significant differences in sex hormone levels between the C. sinensis mono‐infected patients and HCs. This study suggests that C. sinensis co‐infection aggravates the sex hormone disturbance in HBV patients at both chronic hepatitis and cirrhosis stages, providing evidences for potential strategies in disease prevention and treatment. We evaluated the levels of sex hormones in male hepatitis B patients co‐infected with Clonorchis sinensis (C. sinensis). The objectives were divided into six groups, healthy controls (HCs), C. sinensis, chronic hepatitis B (CHB), liver cirrhosis (LC), CHB+ C. sinensis, LC+ C. sinensis. We measured and compared the sex hormone levels for the groups. It was found that C. sinensis co‐infection aggravated the sex hormone disturbance in HBV patients at both chronic hepatitis and cirrhosis stages, providing evidences for potential strategies in disease prevention and treatment.
登录
查看更多内容
影响因子：
2.1
作者：
Nguyen, H. V.;Mollison, L. C.;Yeap, B. B.
通讯作者：
Yeap, B. B.
影响因子：
3.8
作者：
Qian MB;Chen YD;Fang YY;Xu LQ;Zhu TJ;Tan T;Zhou CH;Wang GF;Jia TW;Yang GJ;Zhou XN
通讯作者：
Zhou XN
影响因子：
5.1
作者：
Nelson NP;Easterbrook PJ;McMahon BJ
通讯作者：
McMahon BJ
影响因子：
3.6
作者：
BREIDBART, S;BURK, RD;SAENGER, P
通讯作者：
SAENGER, P
影响因子：
12.7
作者：
Stroffolini, Tommaso;Esvan, Rozenn;Almasio, Piero Luigi
通讯作者：
Almasio, Piero Luigi