Disability weight of Clonorchis sinensis infection: captured from community study and model simulation.
Disability weight of Clonorchis sinensis infection: captured from community study and model simulation.
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DOI：
10.1371/journal.pntd.0001377
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发表时间：
2011-12
影响因子：
3.8
通讯作者：
Zhou XN
中科院分区：
文献类型：
--
作者：
Qian MB;Chen YD;Fang YY;Xu LQ;Zhu TJ;Tan T;Zhou CH;Wang GF;Jia TW;Yang GJ;Zhou XN
华支睾吸虫病是最被忽视的热带疾病之一。它是由摄入含有华支睾吸虫幼虫的生的或未煮熟的鱼或虾引起的，主要流行于中国、韩国和越南等东南亚地区。全球估计高危人口和感染人口分别为 6.01 亿和 3500 万。然而，它仍未被列入全球疾病负担（GBD），也没有可用的伤残权重。伤残权重反映因某种慢性疾病而导致生命值损失的平均程度，范围在0（完全健康）和1（死亡）之间。它是计算任何疾病负担的发病率部分（以伤残调整生命年 (DALY) 为单位）的关键参数。根据华支线虫感染造成的单一后遗症的概率和伤残权重，通过蒙特卡罗模拟可以得到总体伤残权重。单一后遗症的概率是通过一项社区调查得出的，而相应的残疾权重则通过循证的方法从文献中检索。男性和女性的总体残疾权重分别为0.101和0.050。 5-14岁、15-29岁、30-44岁、45-59岁和60岁以上年龄组的总体残疾权重分别为0.022、0.052、0.072、0.094和0.118。有证据表明，残疾重量和每克粪便中鸡蛋的几何平均值（GMEPG）符合对数方程。不同性别和年龄组中华支线虫感染的总体致残权重存在差异。这里获取的伤残权重可用于估计中华支线虫感染的疾病负担。华支睾吸虫病是由于食用了带有华支睾吸虫幼虫的未煮熟的水产品而引起的。据估计，东南亚有数百万人遭受苦难。然而，由于缺乏明确的评估，它仍然是最被忽视的热带病之一，其中没有可用的疾病负担是其中一个重要原因。我们的研究是估计中华支线虫感染致残率的首次尝试，它反映了由于某些情况导致的平均生命值损失，对于计算伤残调整生命年（DALY）的疾病负担至关重要。通过社区调查和文献查阅分别获得华支线虫感染造成单一后遗症的概率和致残率，并通过模型模拟得出总体致残率。结果显示，男性总体致残率高于女性，致残率与感染强度呈正相关，胆结石占主要归因比例。因此，中华线虫感染可导致明显的残疾。这里捕获的残疾可能会促进进一步的研究，并有利于疾病负担的最终估计，这将促进健康意识和干预措施的实施。
Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disability-adjusted life years (DALYs). According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5–14, 15–29, 30–44, 45–59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation. The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection. Clonorchiasis is caused by eating incompletely cooked fishery product which carries the larval of Clonorchis sinensis. Millions of people are estimated to suffer in Southeast Asia. However, it is still among the most neglected tropical diseases due to the lack of clear evaluation, of which no disease burden available is one important reason. Our study is the first attempt to estimate the disability of C. sinensis infection, which reflects the average loss of life value due to some conditions and is crucial for calculating disease burden in terms of disability-adjusted life years (DALYs). After obtaining the probability and disability of single sequelae caused by C. sinensis infection through community investigation and literatures reviewing respectively, the overall disability was captured through model simulation. It was showed the overall disability of the male was higher than that of the female, positive correlation occurred between disability and infection intensity, and gallstone took the major attributable proportion. Thus, C. sinensis infection can cause apparent disability. The disability captured here may promote the further studies and benefit the final estimation of disease burden, which will promote health awareness and implementation of intervention.
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影响因子：
3.8
作者：
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通讯作者：
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DOI：
10.2471/blt.06.033035
发表时间：
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