Safety and efficacy of inhaled nitric oxide treatment for premature infants with respiratory distress syndrome: follow-up evaluation at early school age.
Safety and efficacy of inhaled nitric oxide treatment for premature infants with respiratory distress syndrome: follow-up evaluation at early school age.
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DOI：
10.1111/j.1651-2227.2010.02077.x
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Schreiber MD
中科院分区：
文献类型：
--
作者：
Patrianakos-Hoobler AI;Marks JD;Msall ME;Huo D;Schreiber MD
在一项随机双盲研究中，评估在出生第一周内接受一氧化氮或安慰剂吸入的学龄儿童的长期安全性，并比较其神经发育结果。吸入一氧化氮治疗的儿童在出生时脑室出血和脑室周围白质软化症已被证实减少，并在2岁时减少认知障碍。对167名存活的早产儿中的135名(81%)进行了医疗结果、神经发育评估和学习准备情况的随访研究，时间为5.7±1.0岁。与安慰剂(n=65)相比，接受iNO治疗的儿童(n=70)在生长参数、就学准备或随后住院的需要方面没有差异。然而，接受iNO治疗的儿童不太可能患有多种慢性疾病或对技术的依赖(p=0.05)。接受INO治疗的儿童的功能残疾也较少(p=0.05)。这些结果证明了iNO在早产儿中的长期安全性。此外，iNO治疗可以通过减少严重的持续性疾病和对技术的依赖来改善健康状况，还可以减少早产儿在学龄早期的教育和社区功能残疾的发生率。ClinicalTrials.gov标识：NCT00152542
To assess long-term safety and compare neurodevelopmental outcomes in school age children born prematurely who received inhaled nitric oxide or placebo during the first week of life in a randomized, double blind study. Children treated with inhaled nitric oxide had previously been shown to have decreased intraventricular hemorrhage and periventricular leukomalacia as newborns, and decreased cognitive impairment at 2 years. Follow-up study of medical outcomes, neurodevelopmental assessment and school readiness in 135 of 167 (81%) surviving premature infants seen at 5.7 ± 1.0 years. Compared to placebo (n=65), iNO-treated children (n=70) demonstrated no difference in growth parameters, school readiness, or need for subsequent hospitalization. However, iNO-treated children were less likely to have multiple chronic morbidities or technology-dependence (p=0.05). iNO-treated children also had less functional disability (p=0.05). These results demonstrate the long-term safety of iNO in premature infants. Furthermore, iNO treatment may improve health status by decreasing the incidence of severe ongoing morbidities and technology-dependence, and may also decrease the incidence of educational and community functional disability of premature infants at early school age. clinicaltrials.gov Identifier: NCT00152542
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影响因子：
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