Chronic pain with neuropathic characteristics in diabetic patients: a French cross-sectional study.
Chronic pain with neuropathic characteristics in diabetic patients: a French cross-sectional study.
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DOI：
10.1371/journal.pone.0074195
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hartemann A
中科院分区：
文献类型：
--
作者：
Bouhassira D;Letanoux M;Hartemann A
我们的目的是评估1型和2型糖尿病患者中具有神经病理特征的远端慢性疼痛的患病率及其对生活质量、情绪、焦虑、睡眠和医疗利用的影响。在这项观察性研究中，共有885名患者接受了筛选，766名糖尿病患者（38.7%为1型糖尿病，44.8%为女性，平均年龄：57.2±14.9岁）在3个月内连续入组，85名糖尿病专家在医院部门或私人诊所工作。所有患者均完成一系列调查问卷，以检测下肢慢性疼痛（即超过3个月的每日疼痛），并评估健康相关生活质量（医学结局简表12量表）、睡眠障碍（MOS睡眠量表）、抑郁和焦虑（医院焦虑和抑郁量表）。慢性疼痛患者也进行了评估与7项DN 4访谈问卷，单丝测试和密歇根神经病变筛查仪器（MNSI）。具有神经病理特征的慢性疼痛的总体患病率为20.3% [95%CI 17.4-23.1]。MNSI检查评分表明，这些患者中有80.1%（双侧疼痛患者中有89.5%）的疼痛与多发性神经病有关。慢性疼痛患者的生活质量较差，睡眠障碍，焦虑和抑郁比没有疼痛的患者和神经病理特征的存在是预测这种损害。只有38.6%的患者接受过适当的神经病理性疼痛治疗。具有神经病理特征的慢性疼痛涉及五分之一的糖尿病患者，对生活质量有显著影响，并且未得到充分管理。DN 4问卷和MNSI结果之间的密切相关性表明，神经性疼痛的筛查工具可用于日常实践中识别疼痛性糖尿病多发性神经病。
Our aim was to estimate the prevalence of distal chronic pain with neuropathic characteristics in patients with type 1 and type 2 diabetes mellitus and its impact on quality of life, mood, anxiety, sleep and healthcare utilization. In total, 885 patients were screened and 766 diabetic patients (38.7% with type 1 diabetes mellitus, 44.8% women, mean age: 57.2±14.9 years) were enrolled consecutively over a three-month period in this observational study by 85 diabetes specialists working in a hospital department or in private practice. All the patients completed a series of questionnaires for the detection of chronic pain (i.e. daily pain for more than three months) in the lower limbs and assessment of health-related quality of life (Medical Outcomes Short Form 12 scale), sleep disturbances (MOS sleep scale), depression and anxiety (Hospital Anxiety and Depression scale). Patients with chronic pain were also assessed with the 7-item DN4-interview questionnaire, the monofilament test and the Michigan Neuropathy Screening Instrument (MNSI). The overall prevalence of chronic pain with neuropathic characteristics was 20.3% [95% CI 17.4–23.1]. The MNSI examination score suggested that pain was related to polyneuropathy, in 80.1% of these patients (89.5% of those with bilateral pain). Patients with chronic pain had a poorer quality of life and more sleep disturbances, anxiety and depression than patients without pain and the presence of neuropathic characteristics was predictive of such impairments. Only 38.6% of the patients had received appropriate treatment for neuropathic pain. Chronic pain with neuropathic characteristics concerns one in five diabetic patients, has a significant impact on quality of life and is not adequately managed. The close correlation between the DN4 questionnaire and MNSI results suggests that screening tools for neuropathic pain could be used in daily practice for the identification of painful diabetic polyneuropathy.
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影响因子：
2.3
作者：
Halawa, Mohamed Reda;Karawagh, Abdullah;Hegazy, Ahmed
通讯作者：
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影响因子：
7.4
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影响因子：
5.1
作者：
Attal, N.;Cruccu, G.;Nurmikko, T.
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Nurmikko, T.
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作者：
Malik, R. A.;Veves, A.;Lauria, G.
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影响因子：
16.2
作者：
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通讯作者：
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