Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition.
Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition.
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Snail/PRMT5/NuRD 复合物通过抑制 TET1 导致宫颈癌 DNA 高甲基化
DOI：
10.1038/s41418-021-00786-z
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发表时间：
2021-09
影响因子：
12.4
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Gao J;Liu R;Feng D;Huang W;Huo M;Zhang J;Leng S;Yang Y;Yang T;Yin X;Teng X;Yu H;Yuan B;Wang Y
PRMT5在宫颈癌转移中的生物学功能尚不清楚。在这里，我们报告了PRMT5与转录因子Snail和NuRD(MTA1)复合体物理结合形成一个转录抑制复合体，该复合体催化对称的组蛋白二甲基化和脱乙酰化。这项研究表明，Snail/PRMT5/NuRD(MTA1)复合体针对TET1和E-cadherin等基因，这些基因在上皮-间充质转化(EMT)中起关键作用。这个复合体还影响5mC到5hmC的转换。本研究证实Snail/PRMT5/NuRD(MTA1)复合体在体内外均可促进宫颈癌的侵袭和转移。这项研究还表明，PRMT5在宫颈癌和各种人类癌症中表达上调，PRMT5抑制剂EPZ015666通过抑制TET1的表达和增加5hmC来抑制EMT和宫颈癌细胞的侵袭潜能，提示PRMT5是癌症治疗的潜在靶点。
The biological function of PRMT5 remains poorly understood in cervical cancer metastasis. Here, we report that PRMT5 physically associates with the transcription factor Snail and the NuRD(MTA1) complex to form a transcriptional-repressive complex that catalyzes the symmetrical histone dimethylation and deacetylation. This study shows that the Snail/PRMT5/NuRD(MTA1) complex targets genes, such asTET1andE-cadherin, which are critical for epithelial-mesenchymal transition (EMT). This complex also affects the conversion of 5mC to 5hmC. This study demonstrates that the Snail/PRMT5/NuRD(MTA1) complex promotes the invasion and metastasis of cervical cancer in vitro and in vivo. This study also shows that PRMT5 expression is upregulated in cervical cancer and various human cancers, and the PRMT5 inhibitor EPZ015666 suppresses EMT and the invasion potential of cervical cancer cells by disinhibiting the expression of TET1 and increasing 5hmC, suggesting that PRMT5 is a potential target for cancer therapy.
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异常高甲基化介导的反义lncRNA ZNF667-AS1及其正义基因ZNF667的下调与食管鳞状细胞癌的进展和预后相关
影响因子：
9
作者：
Dong, Zhiming;Li, Shengmian;Guo, Wei
通讯作者：
Guo, Wei
影响因子：
5.3
作者：
Herranz, Nicolas;Pasini, Diego;Peiro, Sandra
通讯作者：
Peiro, Sandra
影响因子：
5.3
作者：
Hou, Zhaoyuan;Peng, Hongzhuang;Rauscher, Frank J., III
通讯作者：
Rauscher, Frank J., III
影响因子：
4.8
作者：
Burgos, Emmanuel S.;Wilczek, Carola;Shechter, David
通讯作者：
Shechter, David
DOI：
10.1038/nrm3758
发表时间：
2014-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
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作者：
通讯作者：
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