[F-18]-fluorodeoxy-D-glucose-positron emission tomography response is associated with outcome for extremity osteosarcoma in children and young adults.
[F-18]-fluorodeoxy-D-glucose-positron emission tomography response is associated with outcome for extremity osteosarcoma in children and young adults.
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作者：
Hawkins DS;Conrad EU 3rd;Butrynski JE;Schuetze SM;Eary JF
对新辅助化疗的反应是影响四肢骨肉瘤(OS)预后的重要因素之一。[F-18]-氟代脱氧-D-葡萄糖(FDG)正电子发射断层扫描(PET)是一种预测组织病理学反应的非侵入性成像方法。为了确定FDG PET反应对OS无进展生存(PFS)的预后价值，我们回顾了华盛顿大学医学中心的经验。对40例四肢OS患者进行FDGPET检查。所有患者均接受新辅助化疗和辅助化疗。分析新辅助化疗前(SUV1)和新辅助化疗(SUV2)后的FDGPET标准摄取值，并与组织病理学反应进行相关性分析。SUV1、SUV2和SUV2/SUV1比值(SUV2：1)的中位数分别为6.8(范围3.0−2 4.1)、2.3(1.2−12.8)和0.36(0.12−1.10)。良好的FDGPET反应定义为SUV22.5或SUV2：1≤0.5。SUV2或SUV2：1的FDG PET反应与组织学反应的符合率分别为58%和68%。SUV2与结果相关(SUV2和≥2.5四年有效率分别为73%和39%，p=0.021。疾病初始阶段和组织学反应均与预后有关。四肢OS的FDGPET成像仅与新辅助化疗的组织学反应部分相关。SUV2<；2.5与PFS的改善有关。未来有必要进行前瞻性研究，以确定FDG PET成像是否是独立于初始疾病阶段的预后预测指标。
Response to neoadjuvant chemotherapy is one of the most powerful prognostic factors for extremity osteosarcoma (OS). [F-18]-fluorodeoxy-D-glucose (FDG) positron emission tomography (PET) is a non-invasive imaging modality to predict histopathologic response. To determine the prognostic value of FDG PET response for progression-free survival (PFS) in OS, we reviewed the University of Washington Medical Center experience. Forty patients with extremity OS were evaluated by FDG PET. All patients received neoadjuvant and adjuvant chemotherapy. FDG PET standard uptake values before (SUV1) and after (SUV2) neoadjuvant chemotherapy were analyzed and correlated with histopathologic response. The median SUV1, SUV2, and ratio of SUV2 to SUV1 (SUV2:1) were 6.8 (range 3.0−24.1), 2.3 (1.2−12.8), and 0.36 (0.12−1.10), respectively. Good FDG PET response was defined as SUV2 < 2.5 or SUV2:1 ≤ 0.5. FDG PET response by SUV2 or SUV2:1 were concordant with histologic response in 58% and 68% of patients, respectively. SUV2 was associated with outcome (four-year PFS 73% for SUV2 < 2.5 versus 39% for SUV2 ≥ 2.5, p=0.021. Initial disease stage and histologic response were both associated with outcome. FDG PET imaging of extremity OS correlated only partially with histologic response to neoadjuvant chemotherapy. SUV2 < 2.5 was associated with improved PFS. Future prospective studies to determine whether FDG PET imaging is a predictor of outcome independent of initial disease stage are warranted.
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影响因子：
45.3
作者：
Meyers, PA;Gorlick, R;Healey, JH
通讯作者：
Healey, JH
影响因子：
6.2
作者：
Schuetze, SM;Rubin, BP;Eary, JF
通讯作者：
Eary, JF
影响因子：
8.8
作者：
Peto R;Pike MC;Armitage P;Breslow NE;Cox DR;Howard SV;Mantel N;McPherson K;Peto J;Smith PG
通讯作者：
Smith PG
影响因子：
45.3
作者：
Hawkins, DS;Schuetze, SM;Eary, JF
通讯作者：
Eary, JF
影响因子：
6.2
作者：
Hawkins, DS;Rajendran, JG;Eary, JF
通讯作者：
Eary, JF