Molecular regulation of cytoskeletal rearrangements during T cell signalling.
Molecular regulation of cytoskeletal rearrangements during T cell signalling.
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T 细胞信号转导过程中细胞骨架重排的分子调控
DOI：
10.1007/400_022
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发表时间：
2006
影响因子：
--
通讯作者：
Kliche S.
中科院分区：
文献类型：
--
作者：
Stradal;Kliche S.
造血系统细胞中细胞骨架的调节对于实现多种生物学功能至关重要。 例如向化学引诱物迁移、吞噬作用或细胞-细胞通讯。这 对于许多类型的T细胞来说尤其如此，它们是适应性免疫的基础。 脊椎动物的系统。肌动蛋白丝周转的失调是已知的参与发展 严重的免疫缺陷或免疫增殖性疾病。因此，信号传导的分子解剖 复合物和效应分子，导致受控的细胞骨架组装，一直是焦点， 在过去，细胞骨架重塑经常被理解为信号传导的终点线， 虽然今天越来越明显的是，肌动蛋白和微管动力学需要适当的 信号传递在许多过程中，如T细胞活化。在许多方面作出了重大努力， 本文的目的是总结目前的知识，肌动蛋白和微管是如何影响免疫功能的。 重组以支持免疫突触和外周神经等多种结构的形成。 细胞迁移过程中的突起。
Regulation of the cytoskeleton in cells of the haematopoietic system is essential for fulfilling diverse tasks such as migration towards a chemoattractant, phagocytosis or cell–cell communication. This is particularly true for the many types of T cells, which are at the foundation of the adaptive immune system in vertebrates. Deregulation of actin filament turnover is known to be involved in the development of severe immunodeficiencies or immunoproliferative diseases. Therefore, molecular dissection of signalling complexes and effector molecules, which leads to controlled cytoskeletal assembly, has been the focus of immunological research in the last decade.In the past, cytoskeletal remodelling was frequently understood as the finish line of signalling, while today it becomes increasingly evident that actin and microtubule dynamics are required for proper signal transmission in many processes such as T cell activation. Significant effort is made in many laboratories to further elucidate the contribution of cytoskeletal remodelling to immune function.The objective of this article is to summarise the current knowledge on how actin and microtubules are reorganised to support the formation of structures as diverse as the immunological synapse and peripheral protrusions during cell migration.
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DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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