Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload.
Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload.
复制标题
循环的视黄醇结合蛋白-4浓度可能反映胰岛素抵抗相关的铁超载。
作者：
Fernández-Real JM;Moreno JM;Ricart W
维生素A结合蛋白4（RBP 4）和胰岛素抵抗之间的联系背后的机制还没有得到很好的理解。铁和维生素A状态之间的相互作用，其中RBP 4是替代品，早已被认识到。我们推测，铁相关的胰岛素抵抗可能是RBP 4引起的胰岛素作用受损的原因。研究设计和方法-在一项重复独立研究中，对中年男性样本（n = 132）的血清铁蛋白和RBP 4浓度以及胰岛素抵抗进行了评估。还研究了2型糖尿病患者缺铁前后的血清RBP 4。最后，在体外脂肪组织中评估了铁对RBP 4释放的影响。在两项独立研究中均观察到循环RBP 4和log血清铁蛋白之间的正相关性（分别为r = 0.35和r = 0.61; P < 0.0001）。血清RBP 4浓度在男性高于女性平行增加铁蛋白水平。在预测血清RBP 4的多元回归分析中，在控制BMI、年龄和稳态模型评估值后，血清铁蛋白对数对RBP 4方差有显著贡献。2型糖尿病患者缺铁后血清RBP 4浓度降低（平均差异百分比-13.7 [95%CI-25.4 to-2.04]; P = 0.024）。铁供体乳铁蛋白导致RBP 4的剂量依赖性脂肪组织释放增加（2.4倍，P = 0.005）和RBP 4表达增加，而脱铁转铁蛋白和去铁胺导致RBP 4释放减少。结论：循环RBP 4和铁储备之间的关系，包括横截面和铁耗竭后，以及体外研究结果表明，铁可能在RBP 4-胰岛素抵抗关系中发挥作用。
OBJECTIVES—The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood. An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized. We hypothesized that iron-associated insulin resistance could be behind the impaired insulin action caused by RBP4. RESEARCH DESIGN AND METHODS—Serum ferritin and RBP4 concentration and insulin resistance were evaluated in a sample of middle-aged men (n = 132) and in a replication independent study. Serum RBP4 was also studied before and after iron depletion in patients with type 2 diabetes. Finally, the effect of iron on RBP4 release was evaluated in vitro in adipose tissue. RESULTS—A positive correlation between circulating RBP4 and log serum ferritin (r = 0.35 and r = 0.61, respectively; P < 0.0001) was observed in both independent studies. Serum RBP4 concentration was higher in men than women in parallel to increased ferritin levels. On multiple regression analyses to predict serum RBP4, log serum ferritin contributed significantly to RBP4 variance after controlling for BMI, age, and homeostasis model assessment value. Serum RBP4 concentration decreased after iron depletion in type 2 diabetic patients (percent mean difference −13.7 [95% CI −25.4 to −2.04]; P = 0.024). The iron donor lactoferrin led to increased dose-dependent adipose tissue release of RBP4 (2.4-fold, P = 0.005) and increased RBP4 expression, while apotransferrin and deferoxamine led to decreased RBP4 release. CONCLUSIONS—The relationship between circulating RBP4 and iron stores, both cross-sectional and after iron depletion, and in vitro findings suggest that iron could play a role in the RBP4–insulin resistance relationship.
登录
查看更多内容
DOI：
10.1080/07315724.1997.10718647
发表时间：
1997-02-01
影响因子：
3.5
作者：
Basualdo, CG;Wein, EE;Basu, TK
通讯作者：
Basu, TK
影响因子：
7.7
作者：
Fernández-Real, JM;Peñarroja, G;Ricart, W
通讯作者：
Ricart, W
影响因子：
158.5
作者：
Graham, Timothy E.;Yang, Qin;Kahn, Barbara B.
通讯作者：
Kahn, Barbara B.
影响因子：
4.2
作者：
Craft, NE
通讯作者：
Craft, NE
影响因子：
11.4
作者：
Quadro, L;Blaner, WS;Gottesman, ME
通讯作者：
Gottesman, ME