A phase II, randomized, controlled trial of acupuncture for reduction of Postcolectomy Ileus.
A phase II, randomized, controlled trial of acupuncture for reduction of Postcolectomy Ileus.
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DOI：
10.1245/s10434-012-2759-7
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发表时间：
2013-04
影响因子：
3.7
通讯作者：
Cassileth B
中科院分区：
文献类型：
--
作者：
Deng G;Wong WD;Guillem J;Chan Y;Affuso T;Yeung KS;Coleton M;Sjoberg D;Vickers A;Cassileth B
术后肠梗阻（POI）会延长住院时间并增加术后并发症的风险。我们进行了一项随机、假手术对照试验，以评估针灸是否比假针灸更有效地降低 POI。接受选择性结肠切除术的结肠癌患者在术后前 3 天随机接受每天两次每次 30 分钟的真针灸或假针灸治疗。确定 GI-3（以下两个事件中的较晚者：患者首次耐受固体食物的时间和患者首次排便或排便的时间）和 GI-2（以下两个事件中的较晚者：患者首次耐受固体食物的时间和患者首次排便的时间）。术后前 3 天每天评估疼痛、恶心、呕吐和止痛药物的使用情况。 90 名患者被随机分组。 81 人接受了分配的干预措施：真针灸组 39 人，假针灸组 42 人，所有患者均接受了主要终点评估。针灸组和假针灸组术后达到 GI-3 的平均时间分别为 149 小时 [标准差 (SD) 71 小时] 和 146 小时 (SD 62 小时)（平均值之间的差异 -2 小时；95% 置信区间 -31, 26；p = 0.9）。次要终点组间未发现显着差异。本研究中提供的真实针灸并没有比假针灸更显着地降低 POI。该研究受到远大于预期的标准差的限制，这表明可能需要进行更大样本量的研究。
Postoperative ileus (POI) prolongs hospital stay and increases risk of postoperative complications. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture reduces POI more effectively than sham acupuncture. Colon cancer patients undergoing elective colectomy were randomized to receive 30 min of true or sham acupuncture twice daily during their first 3 postoperative days. GI-3 (the later of the following two events: time that the patient first tolerated solid food, AND time that the patient first passed flatus OR a bowel movement) and GI-2 (the later of the following two events: time patient first tolerated solid food AND time patient first passed a bowel movement) were determined. Pain, nausea, vomiting, and use of pain medications were evaluated daily for the first 3 postoperative days. Ninety patients were randomized. Eighty-one received the allocated intervention: 39 in the true acupuncture group and 42 in the sham acupuncture group, all evaluated for the primary endpoint. The mean time to GI-3 was 149 h [standard deviation (SD) 71 h] and 146 (SD 62 h) after surgery for the acupuncture group and the sham acupuncture group (difference between means −2 h; 95 % confidence interval −31, 26; p = 0.9). No significant differences were found between groups for secondary endpoints. True acupuncture as provided in this study did not reduce POI more significantly than sham acupuncture. The study was limited by a standard deviation much larger than expected, suggesting that a study with a larger sample size might be required.
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影响因子：
9
作者：
Wolff, BG;Michelassi, F;Wallin, BA
通讯作者：
Wallin, BA
影响因子：
3.9
作者：
Delaney, CP;Weese, JL;Wallin, BA
通讯作者：
Wallin, BA
影响因子：
2.9
作者：
Sugai, GCM;Freire, AD;Mello, LEAM
通讯作者：
Mello, LEAM
DOI：
10.1016/s1079-2104(05)80121-0
发表时间：
1995-04-01
影响因子：
--
作者：
LAO, LX;BERGMAN, S;BERMAN, B
通讯作者：
BERMAN, B
影响因子：
3.8
作者：
Scott, AM;Starling, JR;Harms, BA
通讯作者：
Harms, BA