Lecithin-Based Microemulsions for Targeted Delivery of Ceramide AP into the Stratum Corneum: Formulation, Characterizations, and In Vitro Release and Penetration Studies
Lecithin-Based Microemulsions for Targeted Delivery of Ceramide AP into the Stratum Corneum: Formulation, Characterizations, and In Vitro Release and Penetration Studies
复制标题
用于将神经酰胺 AP 靶向递送至角质层的卵磷脂微乳液：配方、表征以及体外释放和渗透研究
DOI：
10.1007/s11095-012-0899-x
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发表时间：
2013
影响因子：
3.7
通讯作者：
R. Neubert
中科院分区：
文献类型：
--
作者：
F. F. Sahle;H. Metz;J. Wohlrab;R. Neubert
ABSTRACTPurposeTo improve the solubility and penetration of Ceramide AP (CER [AP]) into the stratum corneum that potentially restores the barrier function of aged and affected skin.MethodsCER [AP] microemulsions (MEs) were formulated using lecithin, Miglyol® 812 (miglyol) and water-1,2 pentandiol (PeG) mixture as amphiphilic, oily and hydrophilic components, respectively. The nanostructure of the MEs was revealed using electrical conductivity, differential scanning calorimeter (DSC) and electron paramagnetic resonance (EPR) techniques. Photon correlation spectroscopy (PCS) was used to measure the sizes and shape of ME droplets. The release and penetration of the CER into the stratum corneum was investigated in vitro using a multi-layer membrane model.ResultsThe MEs exhibited excellent thermodynamic stability (>2 years) and loading capacity (0.5% CER [AP]). The pseudo-ternary phase diagrams of the MEs were obtained and PCS results showed that the droplets are spherical in shape and bigger in size. In vitro investigations showed that the MEs exhibited excellent rate and extent of release and penetration.ConclusionsStable lecithin-based CER [AP] MEs that significantly enhance the solubility and penetration of CER [AP] into the stratum corneum were developed. The MEs also have better properties than the previously reported polyglycerol fatty acid surfactant-based CER [AP] MEs.
基于神经酰胺 [EOS] 和 [AP] 的角质层脂质基质的基本纳米结构：中子衍射研究
影响因子：
3.4
作者：
Schröter;Kessner;Kiselev;Neubert
通讯作者：
Neubert