Biologically derived soft conducting hydrogels using heparin-doped polymer networks.
Biologically derived soft conducting hydrogels using heparin-doped polymer networks.
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DOI：
10.1021/nn406019m
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发表时间：
2014-05-27
期刊：
影响因子：
17.1
通讯作者：
Bettinger CJ
中科院分区：
文献类型：
--
作者：
Ding H;Zhong M;Kim YJ;Pholpabu P;Balasubramanian A;Hui CM;He H;Yang H;Matyjaszewski K;Bettinger CJ
柔性和可伸缩电子元件的出现扩大了电子设备的应用范围。柔性设备非常适合电子生物界面，因为机械上允许的结构符合自然组织中发现的曲线结构。这些应用中使用的大多数电子材料表现出0.1-1兆帕数量级的弹性模数。然而，许多电子可兴奋组织在1-10千帕的范围内表现出弹性，比柔性设备中使用的现有组件小几个数量级。这项工作描述了使用生物衍生的肝素作为支架材料来构建具有混合电子/离子导电性和超顺的机械性能的网络。以光交联型肝素-甲基丙烯酸酯水凝胶为模板，控制原位聚合聚苯胺结构的微观结构和掺杂。宏观上，肝素掺杂的聚苯胺水凝胶双网络在1 kHz下的阻抗低至Z=4.17Ω，存储模数G‘=900±100pA。肝素/聚苯胺网络的电导率取决于二次聚苯胺网络的氧化状态和微观结构。此外，肝素/聚苯胺网络支持小鼠成肌细胞的附着、增殖和分化，而不需要任何表面处理。综上所述，这些结果表明，肝素/聚苯胺水凝胶网络具有合适的物理性能，作为一种电子活性生物界面材料，可以与由可兴奋细胞组成的软组织的机械性能相匹配。
The emergence of flexible and stretchable electronic components expands the range of applications of electronic devices. Flexible devices are ideally suited for electronic biointerfaces because of mechanically permissive structures that conform to curvilinear structures found in native tissue. Most electronic materials used in these applications exhibit elastic moduli on the order of 0.1–1 MPa. However, many electronically excitable tissues exhibit elasticities in the range of 1–10 kPa, several orders of magnitude smaller than existing components used in flexible devices. This work describes the use of biologically derived heparins as scaffold materials for fabricating networks with hybrid electronic/ionic conductivity and ultracompliant mechanical properties. Photo-cross-linkable heparin–methacrylate hydrogels serve as templates to control the microstructure and doping of in situ polymerized polyaniline structures. Macroscopic heparin-doped polyaniline hydrogel dual networks exhibit impedances as low as Z = 4.17 Ω at 1 kHz and storage moduli of G′ = 900 ± 100 Pa. The conductivity of heparin/polyaniline networks depends on the oxidation state and microstructure of secondary polyaniline networks. Furthermore, heparin/polyaniline networks support the attachment, proliferation, and differentiation of murine myoblasts without any surface treatments. Taken together, these results suggest that heparin/polyaniline hydrogel networks exhibit suitable physical properties as an electronically active biointerface material that can match the mechanical properties of soft tissues composed of excitable cells.
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影响因子：
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