IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways.
IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways.
复制标题
IL-6 通过两种不同的 BMPR1A 介导途径增强 BMP-2 诱导的骨生成和脂肪生成
DOI：
10.1038/s41419-017-0126-0
复制
发表时间：
2018-02-02
影响因子：
9
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Huang RL;Sun Y;Ho CK;Liu K;Tang QQ;Xie Y;Li Q
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induces a promising bone formation yield but also leads to inflammation-related events, deteriorated bone quality, and fatty tissue formation. We hypothesize that the seemingly contradictory phenomenon of coformation of new bone and excessive adipose tissue in rhBMP-2-induced bone voids may be associated with interleukin-6 (IL-6), which is significantly elevated after application of rhBMP-2/absorbable collagen sponge (rhBMP-2/ACS). Here, we show that IL-6 injection enhances new bone regeneration and induces excessive adipose tissue formation in an rhBMP-2/ACS-induced ectopic bone formation model in rats. In vitro data further show that IL-6 and its soluble receptor sIL-6R synergistically augment rhBMP-2-induced osteogenic and adipogenic differentiation of human BMSCs (hBMSCs) by promoting cell surface translocation of BMPR1A and then amplifying BMPR1A-mediated BMP/Smad and p38 MAPK pathways, respectively. Our study suggests elevated IL-6 may be responsible for coformation of new bone and excessive adipose tissue in rhBMP-2-induced bone voids.
登录
查看更多内容
影响因子：
12.4
作者：
Chen Q;Shou P;Zheng C;Jiang M;Cao G;Yang Q;Cao J;Xie N;Velletri T;Zhang X;Xu C;Zhang L;Yang H;Hou J;Wang Y;Shi Y
通讯作者：
Shi Y
影响因子：
3
作者：
Lee, Kwang-Bok;Taghavi, Cyrus E.;Wang, Jeffrey C.
通讯作者：
Wang, Jeffrey C.
影响因子：
8.2
作者：
Almuraikhy S;Kafienah W;Bashah M;Diboun I;Jaganjac M;Al-Khelaifi F;Abdesselem H;Mazloum NA;Alsayrafi M;Mohamed-Ali V;Elrayess MA
通讯作者：
Elrayess MA
DOI：
10.1016/j.bbrc.2011.05.042
发表时间：
2011-06-10
影响因子：
3.1
作者：
Lee, Jeong Soon;Park, Jin-Hee;Lim, Jung Yul
通讯作者：
Lim, Jung Yul
影响因子：
4.9
作者：
Lee, Jung-Seok;Lee, Sun-Kyoung;Kim, Chang-Sung
通讯作者：
Kim, Chang-Sung