Early exposure to soy isoflavones and effects on reproductive health: a review of human and animal studies.
Early exposure to soy isoflavones and effects on reproductive health: a review of human and animal studies.
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作者：
Dinsdale EC;Ward WE
大豆异黄酮是具有潜在激素活性的植物雌激素，因为其化学结构与17-β-雌二醇相似。大豆异黄酮在整个食品供应和通过补充剂的使用越来越多的可用性，促使人们对慢性病预防和健康维护方面的生物学益处进行广泛研究。虽然大部分研究都集中在成年人身上，但即使与食用更多大豆食品的成年人相比，食用大豆蛋白婴儿配方奶粉的婴儿也会接触到大量的大豆异黄酮。婴儿通过大豆配方食品接触，主要发生在出生到一岁之间，这是一个对饮食和环境化合物特别敏感的发育阶段。这促使研究人员研究大豆异黄酮对后期生殖健康结果的潜在激素影响。这些研究包括最少的人类数据，大多数研究使用动物模型。本综述讨论了当前人类和动物研究的关键方面，并确定了需要调查的关键领域，因为在这一研究领域没有明确的共识。
Soy isoflavones are phytoestrogens with potential hormonal activity due to their similar chemical structure to 17-β-estradiol. The increasing availability of soy isoflavones throughout the food supply and through use of supplements has prompted extensive research on biological benefits to humans in chronic disease prevention and health maintenance. While much of this research has focused on adult populations, infants fed soy protein based infant formulas are exposed to substantial levels of soy isoflavones, even when compared to adult populations that consume a higher quantity of soy-based foods. Infant exposure, through soy formula, primarily occurs from birth to one year of life, a stage of development that is particularly sensitive to dietary and environmental compounds. This has led investigators to study the potential hormonal effects of soy isoflavones on later reproductive health outcomes. Such studies have included minimal human data with the large majority of studies using animal models. This review discusses key aspects of the current human and animal studies and identifies critical areas to be investigated as there is no clear consensus in this research field.
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影响因子：
5.1
作者：
Gilchrist, Janet M.;Moore, Mary Beth;Badger, Thomas M.
通讯作者：
Badger, Thomas M.
DOI：
10.1001/archpedi.1986.02140260065028
发表时间：
1986-12-01
影响因子：
--
作者：
FRENITITULAER, LW;CORDERO, JF;MILLS, JL
通讯作者：
MILLS, JL
影响因子：
9.7
作者：
Doerge, DR;Twaddle, NC;Newbold, RR
通讯作者：
Newbold, RR
影响因子：
10.4
作者：
Jefferson, Wendy N.;Doerge, Daniel;Newbold, Retha
通讯作者：
Newbold, Retha
DOI：
10.1073/pnas.72.10.4172
发表时间：
1975-01-01
影响因子：
11.1
作者：
FRISCH, RE;HEGSTED, DM;YOSHINAGA, K
通讯作者：
YOSHINAGA, K