Tocilizumab therapy for persistent high-grade fever in systemic lupus erythematosus: two cases and a literature review.
Tocilizumab therapy for persistent high-grade fever in systemic lupus erythematosus: two cases and a literature review.
复制标题
托珠单抗治疗系统性红斑狼疮持续高热2例并文献复习
DOI：
10.1177/03000605221088558
复制
发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Ping F
中科院分区：
文献类型：
--
作者：
Chaoyi M;Shrestha B;Hui L;Qiujin D;Ping F
托珠单抗（TCZ）是一种针对白细胞介素（IL）-6受体的人源化免疫球蛋白（IG）G1单克隆抗体。我们报告两例持续高热和系统性红斑狼疮（SLE）谁与TCZ治疗。两名中国女性患者表现为SLE和高热，炎症标志物包括C反应蛋白、红细胞沉降率和IL-6升高，但没有机会性感染的迹象。他们的发烧和其他症状对广谱抗生素、抗真菌药、抗病毒药和糖皮质激素反应不佳。他们都用TCZ治疗。他们的体温在TCZ治疗后恢复正常，其他症状，包括关节痛，逐渐改善。两名患者均接受了随访，迄今为止，他们的病情保持稳定。因此，TCZ可能是对初始抗生素和大剂量糖皮质激素无效的SLE和持续高热患者的替代治疗。
Tocilizumab (TCZ) is a humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the interleukin (IL)-6 receptor. We report on two patients with persistent high-grade fever and systemic lupus erythematosus (SLE) who were treated with TCZ. Two female Chinese patients presented with SLE and high-grade fever, with raised inflammatory markers including C-reactive protein, erythrocyte sedimentation rate, and IL-6, but no signs of opportunistic infections. Their fever and other symptoms responded poorly to broad-spectrum antibiotics, antifungals, antivirals, and glucocorticoids. They were both treated with TCZ. Their body temperatures returned to normal after treatment with TCZ, and other symptoms, including arthralgia, gradually improved. Both patients were followed-up and their conditions remained steady to date. TCZ may thus be an alternative treatment for patients with SLE and persistent high-grade fever who fail to respond to initial antibiotics and high-dose glucocorticoids.
登录
查看更多内容
影响因子：
27.4
作者：
Munroe ME;Lu R;Zhao YD;Fife DA;Robertson JM;Guthridge JM;Niewold TB;Tsokos GC;Keith MP;Harley JB;James JA
通讯作者：
James JA
影响因子：
--
作者：
Petri, Michelle;Orbai, Ana-Maria;Alarcon, Graciela S.;Gordon, Caroline;Merrill, Joan T.;Fortin, Paul R.;Bruce, Ian N.;Isenberg, David;Wallace, Daniel J.;Nived, Ola;Sturfelt, Gunnar;Ramsey-Goldman, Rosalind;Bae, Sang-Cheol;Hanly, John G.;Sanchez-Guerrero, Jorge;Clarke, Ann;Aranow, Cynthia;Manzi, Susan;Urowitz, Murray;Gladman, Dafna;Kalunian, Kenneth;Costner, Melissa;Werth, Victoria P.;Zoma, Asad;Bernatsky, Sasha;Ruiz-Irastorza, Guillermo;Khamashta, Munther A.;Jacobsen, Soren;Buyon, Jill P.;Maddison, Peter;Dooley, Mary Anne;van vollenhoven, Ronald F.;Ginzler, Ellen;Stoll, Thomas;Peschken, Christine;Jorizzo, Joseph L.;Callen, Jeffrey P.;Lim, S. Sam;Fessler, Barri J.;Inanc, Murat;Kamen, Diane L.;Rahman, Anisur;Steinsson, Kristjan;Franks, Andrew G., Jr.;Sigler, Lisa;Hameed, Suhail;Fang, Hong;Ngoc Pham;Brey, Robin;Weisman, Michael H.;McGwin, Gerald, Jr.;Magder, Laurence S.
通讯作者：
Magder, Laurence S.
DOI：
10.1016/j.clim.2016.04.010
发表时间：
2017-12
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Koga T;Ichinose K;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
19.6
作者：
Rovin, BH;Tang, YX;Hebert, LA
通讯作者：
Hebert, LA
影响因子：
4.2
作者：
Cheng, Xiangming;Zhang, Mingxin;Ji, Zhigang
通讯作者：
Ji, Zhigang