Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis.
Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis.
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DOI：
10.3904/kjim.2014.29.2.176
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Hong SY
中科院分区：
文献类型：
--
作者：
Lee JH;Oh MH;Park JS;Na GJ;Gil HW;Yang JO;Lee EY;Hong SY
本研究旨在探讨尿激酶型纤溶酶原激活物（uPA）、uPA受体（uPAR）和纤溶酶原激活物抑制剂（派）-1在伊加肾炎足细胞上的表达。对52例伊加GN患者的肾活检标本进行脱蜡，并进行uPA、派-1和uPAR的免疫组化染色。根据足细胞上uPA和uPAR的表达将活检分为三组：uPA、uPAR和阴性组。比较各组间伊加GN牛津分类变量的患病率。足细胞uPA阳性11例，uPAR阳性38例，派-1均阴性。足细胞上uPA和uPAR的表达较少伴有肾小管间质纤维化。我们的研究结果表明，足细胞uPA/uPAR表达对间质纤维化可能具有保护作用。
The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.
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影响因子：
6.7
作者：
Colman, Robert W.;Wu, Yi;Liu, Yuchuan
通讯作者：
Liu, Yuchuan
影响因子：
4.1
作者：
Tkachuk, Natalia;Kiyan, Julia;Dumler, Inna
通讯作者：
Dumler, Inna
影响因子：
6.7
作者：
Alfano, D;Franco, P;Stoppelli, MP
通讯作者：
Stoppelli, MP
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1097/01.asn.0000064292.37793.fb
发表时间：
2003-05-01
影响因子：
13.6
作者：
Zhang, GQ;Kim, H;Eddy, AA
通讯作者：
Eddy, AA