Nanotheranostics for Image-Guided Cancer Treatment.
Nanotheranostics for Image-Guided Cancer Treatment.
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DOI：
10.3390/pharmaceutics14050917
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发表时间：
2022-04-22
期刊：
影响因子：
5.4
通讯作者：
McNally, Lacey R.
中科院分区：
文献类型：
--
作者：
Dennahy, Isabel S.;Han, Zheng;MacCuaig, William M.;Chalfant, Hunter M.;Condacse, Anna;Hagood, Jordan M.;Claros-Sorto, Juan C.;Razaq, Wajeeha;Holter-Chakrabarty, Jennifer;Squires, Ronald;Edil, Barish H.;Jain, Ajay;McNally, Lacey R.
关键词：
图像引导的纳米治疗诊断学有可能代表癌症治疗的新范式。现代成像和纳米颗粒设计的最新发展为与传统化疗相关的许多问题提供了答案，包括其不分青红皂白的副作用和对耐药性的敏感性。成像是最适合定制癌症治疗的工具之一。图像引导的纳米治疗诊断学领域有可能利用现代成像技术的精确性，并利用其来指导、指示和跟踪特定部位的药物递送，所有这些都可用于进一步在个体和群体水平上定制癌症治疗。图像引导药物递送的使用在临床前和临床试验中已经爆炸式增长，尽管临床转化刚刚开始。本综述将重点介绍肿瘤靶向给药的传统机制，包括分子靶向的使用，以及纳米治疗诊断学设计的基础，重点介绍纳米治疗诊断学在肿瘤中的临床应用。各种特殊工程和有针对性的药物载体，沿着的战略，标记纳米粒子赋予可检测性在不同的成像方式将进行审查。它还将引入图像引导药物输送的新概念，这可能会规避其他技术所遇到的许多问题。最后，我们将回顾目前的障碍，临床翻译的图像引导nanotheranostics和如何克服这些可能。
Image-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susceptibility to drug resistance. Imaging is one of the tools best poised to enable tailoring of cancer therapies. The field of image-guided nanotheranostics has the potential to harness the precision of modern imaging techniques and use this to direct, dictate, and follow site-specific drug delivery, all of which can be used to further tailor cancer therapies on both the individual and population level. The use of image-guided drug delivery has exploded in preclinical and clinical trials although the clinical translation is incipient. This review will focus on traditional mechanisms of targeted drug delivery in cancer, including the use of molecular targeting, as well as the foundations of designing nanotheranostics, with a focus on current clinical applications of nanotheranostics in cancer. A variety of specially engineered and targeted drug carriers, along with strategies of labeling nanoparticles to endow detectability in different imaging modalities will be reviewed. It will also introduce newer concepts of image-guided drug delivery, which may circumvent many of the issues seen with other techniques. Finally, we will review the current barriers to clinical translation of image-guided nanotheranostics and how these may be overcome.
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影响因子：
3.1
作者：
Bagley AF;Ludmir EB;Maitra A;Minsky BD;Li Smith G;Das P;Koong AC;Holliday EB;Taniguchi CM;Katz MHG;Tamm EP;Wolff RA;Overman MJ;Patel S;Kim MP;Tzeng CD;Ikoma N;Bhutani MS;Koay EJ
通讯作者：
Koay EJ
影响因子：
7.4
作者：
Anselmo AC;Mitragotri S
通讯作者：
Mitragotri S
影响因子：
16.1
作者：
Atukorale PU;Covarrubias G;Bauer L;Karathanasis E
通讯作者：
Karathanasis E
影响因子：
2.9
作者：
Castelli, Daniela Delli;Terreno, Enzo;Aime, Silvio
通讯作者：
Aime, Silvio
影响因子：
5.5
作者：
Al Faraj, Achraf;Shaik, Asma Sultana;Al Sayed, Baraa
通讯作者：
Al Sayed, Baraa