Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity.
Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity.
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DOI：
10.1186/1471-2202-12-23
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发表时间：
2011-03-06
期刊：
影响因子：
2.4
通讯作者：
Yoo SS
中科院分区：
文献类型：
--
作者：
Min BK;Bystritsky A;Jung KI;Fischer K;Zhang Y;Maeng LS;Park SI;Chung YA;Jolesz FA;Yoo SS
癫痫是一种常见的神经系统疾病，可归因于神经元不可控的异常高兴奋性。研究了低强度脉冲聚焦超声(FUS)无创抑制戊四氮(PTZ)致痫动物模型(大鼠)癫痫发作的可行性。在诱发癫痫发作后，FUS经颅脑注射两次，每次三分钟，同时接受脑电(EEG)监测。以690 kHz的基频工作的气背球形节段超声换能器(直径：6 cm；曲率半径：7 cm)被用来以100 hz的重复频率向丘脑区域发射0.5毫秒长的超声脉冲序列。实验中使用的声强(130 mW/cm2)完全在临床超声成像安全指南的范围内。与致痫前相比，致痫大鼠致痫后癫痫脑电爆发的发生率明显降低。PTZ诱导的对照组没有接受任何超声波治疗，表现出持续数量的癫痫脑电信号爆发。接受超声波治疗的动物也表现出不那么严重的癫痫行为，这是通过瑞辛评分进行评估的。组织学分析证实，超声波没有对脑组织造成任何损害。这些结果表明，在动物急性癫痫模型上，低强度脉冲超声可以抑制癫痫信号爆发的次数。由于其非侵袭性和空间选择性，FUS可能为癫痫的非侵入性治疗提供新的视角。
Epilepsy is a common neurological disorder, which is attributed to uncontrollable abnormal hyper-excitability of neurons. We investigated the feasibility of using low-intensity, pulsed radiation of focused ultrasound (FUS) to non-invasively suppress epileptic activity in an animal model (rat), which was induced by the intraperitonial injection of pentylenetetrazol (PTZ). After the onset of induced seizures, FUS was transcranially administered to the brain twice for three minutes each while undergoing electroencephalographic (EEG) monitoring. An air-backed, spherical segment ultrasound transducer (diameter: 6 cm; radius-of-curvature: 7 cm) operating at a fundamental frequency of 690 KHz was used to deliver a train of 0.5 msec-long pulses of sonication at a repetitive rate of 100 Hz to the thalamic areas of the brain. The acoustic intensity (130 mW/cm2) used in the experiment was sufficiently within the range of safety guidelines for the clinical ultrasound imaging. The occurrence of epileptic EEG bursts from epilepsy-induced rats significantly decreased after sonication when it was compared to the pre-sonication epileptic state. The PTZ-induced control group that did not receive any sonication showed a sustained number of epileptic EEG signal bursts. The animals that underwent sonication also showed less severe epileptic behavior, as assessed by the Racine score. Histological analysis confirmed that the sonication did not cause any damage to the brain tissue. These results revealed that low-intensity, pulsed FUS sonication suppressed the number of epileptic signal bursts using acute epilepsy model in animal. Due to its non-invasiveness and spatial selectivity, FUS may offer new perspectives for a possible non-invasive treatment of epilepsy.
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影响因子：
3.5
作者：
Fatemi, M;Greenleaf, JF
通讯作者：
Greenleaf, JF
影响因子：
2.4
作者：
FRY, WJ;WULFF, VJ;FRY, FJ
通讯作者：
FRY, FJ
DOI：
10.1016/j.mric.2005.04.008
发表时间：
2005-08-01
影响因子：
1.6
作者：
Jolesz, Ferenc A;Hynynen, Kullervo;Tempany, Clare
通讯作者：
Tempany, Clare
DOI：
10.1007/bf00696354
发表时间：
1973-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
BROWN, AM
通讯作者：
BROWN, AM
影响因子：
3.5
作者：
DINNO, MA;DYSON, M;CRUM, LA
通讯作者：
CRUM, LA