Unilateral heat accelerates bone elongation and lengthens extremities of growing mice.
Unilateral heat accelerates bone elongation and lengthens extremities of growing mice.
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DOI：
10.1002/jor.22812
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Tamski HL
中科院分区：
文献类型：
--
作者：
Serrat MA;Schlierf TJ;Efaw ML;Shuler FD;Godby J;Stanko LM;Tamski HL
线性生长障碍是由广泛的全身性和局部性疾病引起的，这些疾病可导致慢性肌肉骨骼残疾。目前的骨延长方案涉及侵入性手术或药物治疗方案，其仅部分有效。在生长过程中暴露于温暖的环境温度会增加肢体长度，这表明有针对性的加热可以非侵入性地增强骨伸长。我们检验了身体一侧的每日热暴露单侧增加股骨和胫骨长度的假设。小鼠（N = 20）在断奶后用40 °C单侧加热处理40分钟/天，持续14天。未处理的小鼠（N = 6）作为对照。单侧耳（8.8%）、后足（3.5%）、股骨（1.3%）和胫骨（1.5%）长度增加。热处理侧的胫骨伸长率大于12%（15 μm/天）。在处理过程中，温度与睾丸长度延长相关。体重和肱骨长度不受影响。为了测试差异是否在成年人中持续存在，在治疗后7周检查小鼠。在热处理侧，耳面积、后足、股骨和胫骨长度仍显著增加，分别约为6%、3.5%、1%和1%。在未治疗的对照组中不存在左右差异，排除了固有的侧不对称性。这种模型对于设计非侵入性的基于热的疗法以潜在地对抗一系列使儿童衰弱的生长障碍是重要的。
Linear growth failure results from a broad spectrum of systemic and local disorders that can generate chronic musculoskeletal disability. Current bone lengthening protocols involve invasive surgeries or drug regimens, which are only partially effective. Exposure to warm ambient temperature during growth increases limb length, suggesting that targeted heat could noninvasively enhance bone elongation. We tested the hypothesis that daily heat exposure on one side of the body unilaterally increases femoral and tibial lengths. Mice (N = 20) were treated with 40 °C unilateral heat for 40 min/day for 14 days post-weaning. Non-treated mice (N = 6) served as controls. Unilateral increases in ear (8.8%), hindfoot (3.5%), femoral (1.3%), and tibial (1.5%) lengths were obtained. Tibial elongation rate was > 12% greater (15 μm/day) on the heat-treated side. Extremity lengthening correlated with temperature during treatment. Body mass and humeral length were unaffected. To test whether differences persisted in adults, mice were examined 7-weeks post-treatment. Ear area, hindfoot, femoral, and tibial lengths were still significantly increased ~6%, 3.5%, 1%, and 1%, respectively, on the heat-treated side. Left-right differences were absent in non-treated controls, ruling out inherent side asymmetry. This model is important for designing noninvasive heat-based therapies to potentially combat a range of debilitating growth impediments in children.
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DOI：
10.2106/00004623-196345040-00009
发表时间：
1963-01-01
影响因子：
5.3
作者：
GRANBERRY, WM;JANES, JM
通讯作者：
JANES, JM
影响因子：
3.3
作者：
Serrat, Maria A.;Efaw, Morgan L.;Williams, Rebecca M.
通讯作者：
Williams, Rebecca M.
影响因子：
4.1
作者：
Meakin, Lee B.;Sugiyama, Toshihiro;Galea, Gabriel L.;Browne, William J.;Lanyon, Lance E.;Price, Joanna S.
通讯作者：
Price, Joanna S.
影响因子：
3
作者：
BRONSON, FH
通讯作者：
BRONSON, FH
DOI：
10.1038/oby.2002.57
发表时间：
2002-05-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Nagy, TR;Krzywanski, D;Desmond, R
通讯作者：
Desmond, R