Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development.
Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development.
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DOI：
10.1016/j.ydbio.2009.07.029
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发表时间：
2009-10-01
影响因子：
2.7
通讯作者：
Feng, Gen-Sheng
中科院分区：
文献类型：
--
作者：
Hagihara, Kazuki;Zhang, Eric E.;Ke, Yue-Hai;Liu, Guofa;Liu, Jan-Jan;Rao, Yi;Feng, Gen-Sheng
Shp2 is a non-receptor protein tyrosine phosphatase containing two Src homology 2 (SH2) domains that is implicated in intracellular signaling events controlling cell proliferation, differentiation and migration. To examine the role of Shp2 in brain development, we created mice with Shp2 selectively deleted in neural stem/progenitor cells. Homozygous mutant mice exhibited early postnatal lethality with defects in neural stem cell self-renewal and neuronal/glial cell fate specification. Here we report a critical role of Shp2 in guiding neuronal cell migration in the cerebellum. In homozygous mutants, we observed reduced and less foliated cerebellum, ectopic presence of external granule cells and mispositioned Purkinje cells, a phenotype very similar to that of mutant mice lacking either SDF-1α or CXCR4. Consistently, Shp2-deficient granule cells failed to migrate toward SDF-1α in an in vitro cell migration assay, and SDF-1α treatment triggered a robust induction of tyrosyl phosphorylation on Shp2. Together, these results suggest that although Shp2 is involved in multiple signaling events during brain development, a prominent role of the phosphatase is to mediate SDF-1α/CXCR4 signal in guiding cerebellar granule cell migration.
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影响因子：
5.3
作者：
Miyazawa, K;Himi, T;Ishizaki, Y
通讯作者：
Ishizaki, Y
DOI：
10.1073/pnas.95.16.9448
发表时间：
1998-08-04
影响因子：
11.1
作者：
Ma, Q;Jones, D;Springer, TA
通讯作者：
Springer, TA
影响因子：
16.2
作者：
Gauthier, Andree S.;Furstoss, Olivia;Miller, Freda D.
通讯作者：
Miller, Freda D.
影响因子：
64.5
作者：
FURLEY, AJ;MORTON, SB;JESSELL, TM
通讯作者：
JESSELL, TM
DOI：
10.1083/jcb.200210149
发表时间：
2003-04-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Arakawa Y;Bito H;Furuyashiki T;Tsuji T;Takemoto-Kimura S;Kimura K;Nozaki K;Hashimoto N;Narumiya S
通讯作者：
Narumiya S